Prevention and long-term outcomes of naturally occurring canine heartworm infection in primary care settings.

Background: This study had two objectives: first, to examine the association between the history of heartworm preventive purchase compliance and the risk of positive heartworm tests, and second to preliminarily investigate the long-term cardiac outcomes of heartworm disease in dogs that had undergone successful adulticidal therapy.

Methods: A retrospective cohort study design was used for both analyses, using anonymous transaction data from Covetrus (retrospective analysis 1) and anonymized medical records from Banfield Pet Hospital (retrospective analysis 2), both including canine patients across the USA. The first analysis examined the relative risk (RR) of a positive heartworm test in dogs with lapses in heartworm preventive purchase history compared to dogs that had no history of a preventive purchase six to 24 months prior to the test.

Retrospective analyses of heartworm (Dirofilaria immitis) disease and ectoparasite preventive medication compliance in veterinary practices in the USA.

Background: Compliance failure with administration of heartworm (HW) disease preventives has been reported as the main contributor to HW disease incidence in medicalized dogs. This study aimed to evaluate purchase compliance with different canine HW preventive products in the USA.

Methods: Anonymized transaction data from clinics throughout the USA served as the basis for two retrospective analyses.

Long-term and per rectum disposition of Clarithromycin in the desert tortoise (Gopherus agassizii).

The macrolide antibiotic clarithromycin (CLARI) has a wide spectrum of activity and efficacy for Mycoplasma species. In addition, CLARI accumulates during re-dosing of Mojave desert tortoises (Gopherus agassizii). Here, we characterized plasma concentrations after a single dose, after 3.