Synthesis and Bioactivity of Isoflavones from and Some Non-Natural Analogues.

Ficucaricone D () and its 4'-demethyl congener are isoflavones isolated from fruits of that share a 5,7-dimethoxy-6-prenyl-substituted A-ring. Both natural products were, for the first time, obtained by chemical synthesis in six steps, starting from 2,4,6-trihydroxyacetophenone. Key steps are a microwave-promoted tandem sequence of Claisen- and Cope-rearrangements to install the 6-prenyl substituent and a Suzuki-Miyaura cross coupling for installing the B-ring.

A new flavonol derivative and other compounds from the leaves of Schum with activity against multidrug-resistant bacteria.

Investigation of the leaves of Schum led to the isolation and identification of a new flavonol derivative, 6-C-methylquercetin-3,4'-dimethyl ether () together with eleven known compounds (-), with two of them ( and ) obtained as a mixture. Their structures were established by extensive spectroscopic analyses. Antibacterial activity of compound as well as the reference antibiotic, ciprofloxacin was tested on Gram-negative multidrug-resistant bacteria overexpressing active efflux pumps, and against methicillin-resistant strains of (MRSA).