Publications by authors named "Jenifer N Nalbandian"
Article Synopsis
- The study discusses how allylic ethers of kojic acid can undergo a chemical reaction known as Claisen rearrangement.
- This reaction is facilitated by a catalyst called zinc triflate.
- As a result, the process produces C-allylated kojic acids in varying yields, from moderate to good.
Background: The primary mode of action for cis-diamminedichloroplatinum (II), referred to as cisplatin, toward the treatment of solid malignancies is through formation of cross-links with DNA at purine sites, especially guanines.
Methods: We prepared oligodeoxyribonucleotides (ODNs) containing a 1,2-GpG, 1,2-ApG, or 1,3-GpXpG cisplatin intrastrand cross-link and the corresponding ODNs modified with (15)N2-labeled cisplatin, and characterized these ODNs with electrospray ionization mass spectrometry (ESI-MS) and tandem MS (MS/MS). We also employed LC-MS/MS to characterize the digestion products of these ODNs after treatment with a cocktail of 4 enzymes (nuclease P1, phosphodiesterases I and II, and alkaline phosphatase).