Mucopolysaccharidosis patients have reduced functional capacity.

Introduction: Mucopolysaccharidoses (MPSs) are a group of rare diseases caused by an intralysosomal accumulation of glycosaminoglycans, resulting in a multisystemic clinical condition characterized by variable degrees of physical-functional impairment.

Objective: To evaluate the functional capacity (FC) of MPS patients and compare with a healthy control group.

Methods: This is a cross-sectional study of 6- to 39-year-old patients followed at a medical reference center and compared with their control peers, matched by age and sex.