The Pretreatment Neutrophil-to-Lymphocyte Ratio is a Prognostic Determinant of T3-4 Hypopharyngeal Squamous Cell Carcinoma.

Objective: This study aimed to investigate the clinicopathological factors that influence recurrence and survival in patients who undergo operations for T3-4 hypopharyngeal squamous cell carcinomas (SCCs).

Materials And Methods: One hundred and five patients who underwent surgery between 2001 and 2008 for advanced hypopharyngeal SCCs were consecutively enrolled and reviewed.

Results: The pretreatment neutrophil-to-lymphocyte ratio (NLR; median 3.

Lymph Node Ratio Predicts Recurrence and Survival for Patients with Resectable Stage 4 Hypopharyngeal Cancer.

Background: This study aimed to investigate the clinicopathologic prognostic predictors of stage 4 hypopharyngeal cancer and to extend the traditional tumor-node-metastasis classification system to advance its predictive ability.

Methods: The study enrolled 120 patients with pathologically stage 4 hypopharyngeal cancer treated with pharyngolaryngectomy and neck dissection between 2001 and 2007.

Results: The study showed a 5-year overall survival (OS) of 44.

Evaluation of swallowing disorders by use of transnasal esophagoscopy in patients treated for head and neck cancer.

Background: The purposes of this study were to identify an index of symptoms and signs of swallowing disorders that indicate the occurrence of local recurrence or second primary malignancy and to evaluate the application of transnasal esophagoscopy in patients treated for head and neck squamous cell carcinoma (HNSCC).

Methods: Patients treated for HNSCC with swallowing disorders who received transnasal esophagoscopy examinations between January 2010 and June 2014 were included in this study. Local recurrence and second primary malignancy were pathologically diagnosed.

The impact of perineural invasion and/or lymphovascular invasion on the survival of early-stage oral squamous cell carcinoma patients.

Background: For early-stage oral squamous cell carcinoma (OSCC) patients, the impact of perineural invasion (PNI) and lymphovascular invasion (LVI) on disease control and survival has not been clarified.

Methods: The medical records of all early-stage OSCC patients who underwent curative surgery between 2004 and 2009 were reviewed.

Results: A total of 442 early stage patients were included in this study.

The clinical predictive factors for subsequent distant metastasis in patients with locoregionally advanced oral squamous cell carcinoma.

Objectives: Only a small portion of the patients with locoregionally advanced oral squamous cell carcinoma (OSCC) experience subsequent distant metastasis. This study is to evaluate the occurrence of distant metastasis after curative treatment and to explore the predictive factors for subsequent distant metastasis in patients with locoregionally advanced OSCC.

Materials And Methods: The medical records of all patients with locoregionally advanced OSCC without distant metastasis at the time of diagnosis (AJCC stage III, IV but not IVC) who underwent curative surgery with or without adjuvant radiation between 2004 and 2009 were retrospectively reviewed.

The determining risk factors for treatment outcomes in patients with squamous cell carcinoma of the hard palate.

Background: The determining risk factors for patients with squamous cell carcinoma of the hard palate are not well verified.

Methods: Medical records from our facility of all patients with squamous cell carcinoma of the hard palate receiving curative surgery between March 2003 and May 2009 were reviewed.

Results: Seventy-eight patients were enrolled in the study.

Clinicopathological features of salivary and non-salivary adenoid cystic carcinomas.

Adenoid cystic carcinoma (ACC), commonly from salivary glands, is known for its insidious local growth and usually protracted clinical course. ACC developing from non-salivary glands (i.e.

Salvage treatment for isolated regional failure of nasopharyngeal carcinoma after primary radiotherapy.

Background: Isolated regional failure of nasopharyngeal carcinoma (NPC) after primary treatment is traditionally treated with radical neck dissection (RND). The roles of modified radical neck dissection (MRND) and postoperative radiotherapy after salvage surgery currently remain unclear.

Methods: Medical records from our facility of all NPC patients with isolated regional failure after complete primary radiotherapy and receipt of radical surgery as a part of salvage treatment between January 1985 and December 2004 were retrospectively reviewed.

Prognostic factors of unknown primary head and neck squamous cell carcinoma.

Objective: To evaluate the prognostic factors of unknown primary head and neck squamous cell carcinoma (HNSCC).

Study Design: Retrospective study.

Subjects: Patients with unknown primary HNSCC from 1980 to 2000 were included.

Malignant parotid tumor and facial palsy.

Objective: To evaluate risk factors for postoperative facial palsy in patients with parotid carcinoma.

Study Design And Setting: We conducted a retrospective chart review of patients with parotid carcinoma who underwent parotidectomy at National Taiwan University Hospital from 1980 to 2000.

Results: Eighty-eight patients with a mean age of 53 +/- 17 y were recruited.

Specific induction of the high-molecular-weight microtubule-associated protein 2 (hmw-MAP2) by betel quid extract in cultured oral keratinocytes: clinical implications in betel quid-associated oral squamous cell carcinoma (OSCC).

Betel quid (BQ) chewing, a popular habit in numerous Asian countries including India and Taiwan, has a strong correlation with an increased risk of oral squamous cell carcinoma (OSCC). While substantial efforts have been made to test the cytotoxic, genotoxic and mutagenic effects of BQ extract and its components, the disease mechanisms underlying BQ-induced oral carcinogenesis remain obscure. Here, we show that a neuronal protein, microtubule-associated protein 2 (MAP2), was induced by BQ extract in cultured normal human oral keratinocytes (NHOKs).