Publications by authors named "Jena C Jacobs"
Article Synopsis
- Managing large skin defects after Mohs surgery can be tough, especially in areas with low skin elasticity, requiring complex reconstruction techniques to ensure good results.
- A 78-year-old man with basal cell carcinoma underwent Mohs surgery, which left a 1.5 x 1.5 cm defect on his ear.
- The authors successfully used a bilateral pedicle advancement flap for closure, a rare method in dermatologic surgery, leading to excellent outcomes and no complications after 10 months.
An 85-year-old white male presented with a basal cell carcinoma on the right cheek, treated with Mohs micrographic surgery, resulting in a 5.8 x 3.2 cm defect across multiple facial subunits.
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- Metastatic melanoma often avoids current treatments that trigger cell death through apoptosis, suggesting the need for therapies that target different cell-death pathways.
- Doramectin, previously effective in neuroblastoma by promoting autophagy, was tested on B16F10 melanoma cells to see if it induces similar effects.
- Results revealed that doramectin decreased cell growth and caused apoptotic characteristics in melanoma cells, but increased autophagy wasn't detected, leading to the conclusion that doramectin may offer a new mechanism for inducing cell death in melanoma treatment.
Shikonin Causes Non-apoptotic Cell Death in B16F10 Melanoma.
Anticancer Agents Med Chem
September 2023
Background: Melanoma treatment is highly resistant to current chemotherapeutic agents. Due to its resistance towards apoptotic cell death, non-apoptotic cell death pathways are sought after.
Objective: We investigated a Chinese herbal medicine, shikonin, and its effect on B16F10 melanoma cells in vitro.