Gymnema saponin-induced lipid flip-flop identifies rigid membrane phenotype of methicillin resistant S. aureus and enhances it's antibiotic susceptibility.

Our previous study revealed that lipid flip-flop inducing phytochemicals from Gymnema sylvestre increase membrane permeability of antimicrobials in S. aureus. However, their lipid flipping and membrane permeabilizing effect on methicillin resistant S.

Complexities of riverfront development for the hilly city of Paonta Sahib in India.

The rapid urbanization, industrial growth, and socio-cultural activities along riverbanks in hilly cities are transforming land use and intensifying water infrastructure challenges. Paonta Sahib, a culturally significant town in Himachal Pradesh on the Yamuna River, along the foothills of the Himalayas exemplifies these pressures due to its religious tourism, industrialization, and mining activities. This study explores sustainable riverfront development at Paonta Sahib, addressing socio-cultural, environmental, and technical concerns essential for eco-sensitive urban planning.

Transdermal Buprenorphine Patch in the Management of Postoperative Acute Pain Following Mandibular Resection and Reconstruction.

Background: Transdermal buprenorphine is used for the management of postoperative pain. Its effectiveness for the postoperative pain management following mandibular resection and reconstruction has yet to be evaluated.

Purpose: To evaluate the efficacy of transdermal buprenorphine patch (TBP) in managing postoperative pain after mandibular resection and reconstruction with anterior iliac crest graft.

Alzheimer's disease mortality among taxi and ambulance drivers: population based cross sectional study.

Objective: To analyze mortality attributed to Alzheimer's disease among taxi drivers and ambulance drivers, occupations that demand frequent spatial and navigational processing, compared with other occupations.

Design: Population based cross-sectional study.

Setting: Use of death certificates from the National Vital Statistics System in the United States, which were linked to occupation, 1 January 2020-31 December 2022.

Coaching inexperienced clinicians before a high stakes medical procedure: randomized clinical trial.

Objective: To assess whether training provided to an inexperienced clinician just before performing a high stakes procedure can improve procedural care quality, measuring the first attempt success rate of trainees performing infant orotracheal intubation.

Design: Randomized clinical trial.

Setting: Single center, quaternary children's hospital in Boston, MA, USA.

Intraosseous Mucoepidermoid Carcinoma in the Mandible: A Report of Two Cases and Literature Review.

Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of salivary glands.It usually occurs in major salivary glands. The occurrence of intraosseous MEC (IMEC) is rare and is usually seen in the mandibular premolar and molar regions.

Transforming Hospital Housekeeping: The Kayakalp Journey.

Introduction: The Kayakalp guidelines for public healthcare facilities under the Swachh Bharat Abhiyan (Clean India Mission) focus on improving sanitation, cleanliness, and infection control at public hospitals in India. This study was conducted in a 960-bed tertiary-level teaching hospital in eastern India. Housekeeping has been a challenge in public institutions, with factors like overcrowding and resource constraints.

Solution-Crystalized AgBiS Films for Solar Cells Generating a Photo-Current Density Over 31 mA cm.

In response to the toxic heavy metal absorbers in perovskite solar cells (PSCs), this work focuses on the development of an environmentally friendly simple solution-processed infrared (IR) absorber. In this work, a simple solution-crystallized IR-absorbing AgBiS film is reported by spin-coating silver, bismuth nitrates, and thiourea dissolved in dimethylformamide (DMF) to produce thick AgBiS film. Extensive optimization of the precursor concentrations thicknesses and conductive substrates used allow for obtaining 250 nm AgBiS film with different crystal sizes.

Smear layer removal and antimicrobial efficacy of chitosan as a root canal irrigant: a systematic review of in-vitro studies.

This systematic review was designed to answer the following question: Does chitosan provide better smear layer removal and antimicrobial efficacy than other root canal irrigants? A literature search was done using electronic databases PubMed, Scopus, Web of Science, Cochrane Library, EBSCO host, Grey Literature Report, and Open Grey from inception to June 18, 2024. The reference lists of included articles were also hand-searched. Two reviewers independently assessed the studies' eligibility based on the inclusion and exclusion criteria and performed data extraction.

Trend, Pattern, and Prevalence of Adverse Pregnancy Outcomes among Women of Reproductive Age in India, 1992-2021.

Background: Adverse pregnancy outcomes (APOs) are the most important vital statistics used to assess maternal health and child health statistics. They are an indicator of the quality of maternal and child health care services, i.e.

Hindi translation and validation of the English version of the gastrointestinal symptom rating scale questionnaire: An observational study.

Background: The gastrointestinal symptom rating scale (GSRS) is a questionnaire in English language which is designed to assess the clinical symptoms in patients with irritable bowel syndrome (IBS) and peptic ulcer disease. This validated scale has questions on around 15 items and has been validated in patients with dyspepsia and IBS.

Aim: To translate and validate the English version of the GSRS questionnaire to the Hindi version.

Dietary behaviour, attitude and food perceptions of patients with ulcerative colitis - An observational study.

Background: Dietary knowledge, perception and practices may have a role in determining the nutritional status of patients with inflammatory bowel disease (IBD). However, the assessment of these patterns has infrequently been done in developing countries. We aimed to evaluate patients with ulcerative colitis (UC) about their dietary beliefs, practices and changes after the diagnosis.

Divorce Among Surgeons and Other Physicians in the United States.

Objective: To compare divorce prevalence among surgeons with that of nonsurgeon physicians.

Summary Background Data: The demanding nature of a career in surgery uniquely challenges the social well-being of a surgeon; however, its impact on marital health has not yet been well described.

Methods: A cross-sectional study was conducted using publicly available US Census data from 2017 to 2021 to investigate the prevalence of divorce across different occupations.

Osmolyte-induced conformational stabilization of a hydrophobic polymer.

Elucidating the mechanistic role of osmolytes on conformations of hydrophobic prototypical macromolecules in principle is the stepping stone towards understanding the effect of osmolytes on proteins. Motivated by this, we use equilibrium simulations and umbrella sampling techniques to dissect the underlying mechanism of osmolyte-induced conformational stability of a hydrophobic polymer. Our results unveil a remarkable osmolyte-dependent conformational stabilization of the polymer.

COVID-19 School Closures Were Associated With A Decline In Employment For Female Nurses With Young Children.

COVID-19-related school closures may have had unintended consequences affecting the ability of health professionals with school-age children to work-particularly female professionals, who often have disproportionate child care responsibilities. We combined labor-force participation data from the Current Population Survey with measures of school closures based on cell phone mobility data to examine the association between local school closures and labor supply among female nurses during the COVID-19 pandemic. During the six months after large-scale closure of schools at the end of the 2019-20 school year (March-August 2020), among counties with above-median school closure rates, the employment rate of female nurses with young children declined by 12.

Selective deletion of from mouse cerebellar Purkinje neurons drives sex-specific behavioral impairments linked to autism.

There is a striking sex bias in the prevalence and severity of autism spectrum disorder (ASD) with 80% of diagnoses occurring in males. Because the molecular etiology of ASD is likely combinatorial, including interactions across multiple genetic and environmental factors, it is difficult to investigate the physiological mechanisms driving sex-specific differences. Loss of function mutations in result in dysregulated mTORC1 signaling and underlie a multi-system disorder known as tuberous sclerosis (TSC).

Dynamic swarms regulate the morphology and distribution of soft membrane domains.

We study the dynamic structure of lipid domain inclusions embedded within a phase-separated reconstituted lipid bilayer in contact with a swarming flow of gliding filamentous actin. Passive circular domains transition into highly deformed morphologies that continuously elongate, rotate, and pinch off into smaller fragments, leading to a dynamic steady state with ≈23× speedup in the relaxation of the intermediate scattering function compared with passive membrane domains driven by purely thermal forces. To corroborate experimental results, we develop a phase-field model of the lipid domains with two-way coupling to the Toner-Tu equations.

Measuring surface energy of solid surfaces using centrifugal adhesion balance.

The standard way to evaluate the solid surface energy using probe liquids relies on contact angle measurements. The measured contact angles rely on visible means and are different from their nanoscopic thermodynamic values. This compromises the surface-energy predictions so much that the surface energy-values can be hundreds of percentages higher than expected based on comparisons with different methods as reported in several studies.