A network pharmacology-based strategy to explore the pharmacological mechanisms of Antrodia camphorata and antcin K for treating type II diabetes mellitus.

Background: Diabetes mellitus is a chronic carbohydrate metabolism disorder, which could develop a series of complications and thus lead to poor quality of life or even mortality. Antrodia camphorata is a rare parasitic fungus and has been proven to be effective for treating type II diabetes.

Purpose: This study aims to evaluate the anti-diabetic activities of A.

Chemical constituents from the dish-cultured and their cytotoxic activities.

One new meroterpenoid, antroquinonol Y (), a new ergostane-type sterol, antcamphin Y (), and a new ergostane-type triterpenoid, antcamphin Z (), together with 10 known ones (), were isolated from the dish-cultured fungus . Their structures were characterized by extensive NMR and HRESIMS data analyses. The absolute configurations were elucidated by experimental and calculated electronic circular dichroism (ECD) spectral analyses and chemical semi-synthesis.

Hepatoprotective activities of Antrodia camphorata and its triterpenoid compounds against CCl-induced liver injury in mice.

Ethnopharmacology Relevance: Antrodia camphorata (AC) is a rare and precious fungus indigenous to Taiwan used as a traditional medicine for the treatment of liver injury. Triterpenoids are the major bioactive constituents of A. camphorata and have been reported to possess hepatoprotective activities.