Cell fate conversion prediction by group sparse optimization method utilizing single-cell and bulk OMICs data.

Cell fate conversion by overexpressing defined factors is a powerful tool in regenerative medicine. However, identifying key factors for cell fate conversion requires laborious experimental efforts; thus, many of such conversions have not been achieved yet. Nevertheless, cell fate conversions found in many published studies were incomplete as the expression of important gene sets could not be manipulated thoroughly.

On stability analysis for generalized Minty variational-hemivariational inequality in reflexive Banach spaces.

The stability for a class of generalized Minty variational-hemivariational inequalities has been considered in reflexive Banach spaces. We demonstrate the equivalent characterizations of the generalized Minty variational-hemivariational inequality. A stability result is presented for the generalized Minty variational-hemivariational inequality with -pseudomonotone mapping.

A modified viscosity implicit-type proximal point algorithm for monotone inclusions and asymptotically nonexpansive mappings in Hadamard spaces.

The purpose of this article is to propose a modified viscosity implicit-type proximal point algorithm for approximating a common solution of a monotone inclusion problem and a fixed point problem for an asymptotically nonexpansive mapping in Hadamard spaces. Under suitable conditions, some strong convergence theorems of the proposed algorithms to such a common solution are proved. Our results extend and complement some recent results in this direction.

Abnormal cortical-basal ganglia network in amyotrophic lateral sclerosis: A voxel-wise network efficiency analysis.

Evidence suggests that dysfunctional cortical-basal ganglia (CBG) network plays important roles in the motor symptoms in amyotrophic lateral sclerosis (ALS). However, little effort has been made to investigate the functional abnormalities of CBG network in ALS. Here, we constructed voxel-wise CBG networks using the resting-state fMRI data of 20 patients with ALS and 21 normal controls, and characterized the differences of their efficiency parameters between the two groups.