Publications by authors named "Jen Cornick"
Streptococcus pneumoniae causes substantial mortality among children under 5-years-old worldwide. Polysaccharide conjugate vaccines (PCVs) are highly effective at reducing vaccine serotype disease, but emergence of non-vaccine serotypes and persistent nasopharyngeal carriage threaten this success. We investigated the hypothesis that following vaccine, adapted pneumococcal genotypes emerge with the potential for vaccine escape.
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- Bacterial germs can cause serious diarrhea in kids, but doctors usually only give medicine for certain types like dysentery or cholera.
- A study in seven countries tested a medicine called azithromycin on young children with watery diarrhea and found it helped reduce diarrhea and hospital visits for those likely infected with bacteria.
- The results suggest that treating watery diarrhea suspected to be caused by bacteria with azithromycin can be beneficial for children.
Article Synopsis
- The introduction of pneumococcal conjugate vaccines (PCVs) has effectively reduced invasive pneumococcal diseases but led to the rise of non-vaccine serotypes, notably serotype 15A, linked to clonal complex 63 (CC63).
- A study analyzed 865 isolates of CC63 from the USA and globally, focusing on their serotypes and resistance to antibiotics, revealing a significant increase in serotype 15A after PCV implementation.
- The research indicates that the CC63 lineage, especially the 15A sub-lineage, is widely distributed and predominantly multidrug-resistant, emphasizing the need for ongoing monitoring of these strains.
The SARS-CoV-2 Omicron variant has resulted in a high number of cases, but a relatively low incidence of severe disease and deaths, compared to the pre-Omicron variants. Therefore, we assessed the differences in symptom prevalence between Omicron and pre-Omicron infections in a sub-Saharan African population. We collected data from outpatients presenting at two primary healthcare facilities in Blantyre, Malawi, from November 2020 to March 2022.
View Article and Find Full Text PDFBackground: Azithromycin mass drug administration (MDA) could reduce child mortality. However, macrolide resistance, which has generally been reported to develop after whole-community MDA for trachoma control, is a concern, and it has less commonly been studied in the context of treating children to reduce mortality. Here, we report on macrolide resistance after biannual azithromycin MDA at the Malawi site of the MORDOR study.
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