Publications by authors named "Jemma E Clary"
Article Synopsis
- G3BP1 and G3BP2 are proteins that help form stress granules in cells during stress, like viral infections, but SARS-CoV-2's nucleocapsid (N) protein stops this process.
- The study identifies a specific mutation (N-F17A) in the N protein that prevents its interaction with G3BP1/2, leading to an inability to inhibit stress granule formation.
- This disruption results in lower viral replication and reduced illness in experimental models, showing that the G3BP1-N interaction is crucial for SARS-CoV-2’s ability to replicate and cause disease.
