ACS Appl Mater Interfaces
December 2024
Ingestible devices (ID) provide a safe and noninvasive method for monitoring, diagnosing, and delivering drugs to specific sites in the human body, particularly within the gastrointestinal (GI) tract. However, the GI environment is highly acidic and humid, which can cause IDs to fail, and their corrosion in the acidic environment can cause leaching of toxic metal ions, thereby substantially limiting their long-term use. Thus, an efficient method is required to protect IDs, especially in the chemically and mechanically harsh GI environment.
View Article and Find Full Text PDFThe increasing incidence of serious bacterial keratitis, a sight-threatening condition often exacerbated by inadequate contact lens (CLs) care, highlights the need for innovative protective technology. This study introduces a long-lasting antibacterial, non-cytotoxic, transparent nanocoating for CLs via a solvent-free polymer deposition method, aiming to prevent bacterial keratitis. The nanocoating comprises stacked polymer films, with poly(dimethylaminomethyl styrene-co-ethylene glycol dimethacrylate) (pDE) as a biocompatible, antibacterial layer atop poly(2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane) (pV4D4) as an adhesion-promoting layer.
View Article and Find Full Text PDFHuman pluripotent stem cells (hPSCs), encompassing human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), hold immense potential in regenerative medicine, offering new opportunities for personalized cell therapies. However, their clinical translation is hindered by the inevitable reliance on xenogeneic components in culture environments. This study addresses this challenge by engineering a fully synthetic, xeno-free culture substrate, whose surface composition is tailored systematically for xeno-free culture of hPSCs.
View Article and Find Full Text PDFvascularized cancer models utilizing microfluidics have emerged as a promising tool for mechanism study and drug screening. However, the lack of consideration and preparation methods for cancer cellular sources that are capable of adequately replicating the metastatic features of circulating tumor cells contributed to low relevancy with experimental results. Here, we show that the properties of cancer cellular sources have a considerable impact on the validity of the metastasis model.
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