Publications by authors named "Jelle Streefkerk"
Cell Chem Biol
August 2018
Article Synopsis
- Prolyl oligopeptidase (POP) is a promising target for treating cognitive and neurodegenerative disorders, but existing inhibitors have limitations like short action duration and poor brain access.
- Researchers have developed the first irreversible and selective POP inhibitors that can effectively cross the blood-brain barrier.
- These new inhibitors demonstrate strong effectiveness in inactivating POP at low concentrations and show over 1,000-fold selectivity against related proteases, making them potential candidates for therapeutic use.
