Clinicopathological characteristics of Epstein-Barr virus-positive gastric cancer in Latvia.

Objective: Epstein-Barr virus (EBV)-associated gastric cancer has been proposed to be a distinct gastric cancer molecular subtype. The prognostic significance of EBV infection in gastric cancer remains unclear and needs further investigation. Our study aimed to analyze EBV-positive and EBV-negative gastric cancer patients regarding their personal and tumor-related characteristics, and compare their overall survival.

Epidemiology of Helicobacter pylori infection.

This review provides the most recent data concerning the epidemiology of Helicobacter pylori infection. Overall, the trend of declining prevalence of H. pylori infection is continuing, with major evidence available from studies in Europe.

Pepsinogen test for the evaluation of precancerous changes in gastric mucosa: a population-based study.

Aims: The aim of the study was to evaluate the rationale of blood pepsinogen (PG) testing in population based screening settings.

Methods: Participants from a cross-sectional population-based study of cardiovascular risk factors in Latvia were invited to participate in the current study. Pepsinogen I and II were measured in blood samples taken during the initial study and at follow-up; upper gastrointestinal endoscopy was performed.