Broadly tunable continuous-wave Tm,Ho:SrF and Tm,Ho:BaF lasers.

We report on the first, to our knowledge, room-temperature continuous-wave laser operation of Tm,Ho-codoped barium and strontium fluoride crystals at ∼2.1 µm. The 3 at.

Very rare near-haploid acute lymphoblastic leukemia resistant to immunotherapy and CAR-T therapy in 19-year-old male patient.

Near-haploid acute lymphoblastic leukemia is rare subgroup of the disease, which is very important due to very poor prognosis and resistance to treatment including novel monoclonal antibodies and CAR-T therapy.

The Absence of Retroelement Activity Is Characteristic for Childhood Acute Leukemias and Adult Acute Lymphoblastic Leukemia.

Retroelements (RE) have been proposed as important players in cancerogenesis. Different cancer types are characterized by a different level of tumor-specific RE insertions. In previous studies, small cohorts of hematological malignancies, such as acute myeloid leukemia, multiple myeloma, and chronic lymphocytic leukemia have been characterized by a low level of RE insertional activity.

Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant.

The aim of the present study was to evaluate the significance of low-level minimal/measurable residual disease (MRD) during early consolidation treatment in adult BCR-ABL1-negative acute lymphoblastic leukaemia. The MRD load was monitored by immunoglobulin/T-cell receptor rearrangements and assessed as negative [complete MRD response (CMR)], positive non-quantifiable (MRDnq) and positive quantifiable (MRDq). MRDnq before the first and second consolidation blocks had a comparable negative effect on survival as MRDq.

LYmphoid NeXt-Generation Sequencing (LYNX) Panel: A Comprehensive Capture-Based Sequencing Tool for the Analysis of Prognostic and Predictive Markers in Lymphoid Malignancies.

B-cell neoplasms represent a clinically heterogeneous group of hematologic malignancies with considerably diverse genomic architecture recently endorsed by next-generation sequencing (NGS) studies. Because multiple genetic defects have a potential or confirmed clinical impact, a tendency toward more comprehensive testing of diagnostic, prognostic, and predictive markers is desired. This study introduces the design, validation, and implementation of an integrative, custom-designed, capture-based NGS panel titled LYmphoid NeXt-generation sequencing (LYNX) for the analysis of standard and novel molecular markers in the most common lymphoid neoplasms (chronic lymphocytic leukemia, acute lymphoblastic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma).

Genomic landscape of B-other acute lymphoblastic leukemia in an adult retrospective cohort with a focus on -like subtype.

Introduction: -like acute lymphoblastic leukemia (ALL) is a high-risk disease with a complex genomic background. Though extensively studied, data on the frequency and mutual associations of present mutations are still incomplete in adult patients. This retrospective study aims to map the genomic landscape of B-other ALL in a cohort of adult patients with a focus on the -like ALL subtype.

Long-pulse 4.4-4.6 μm laser oscillations of Fe ions in a ZnMnSe (x = 0.3) crystal pumped by a 1940 nm Tm fiber laser through Cr → Fe energy transfer.

Millisecond-pulse laser operation of Fe ions at 78 K is demonstrated in the ZnMnSe:Fe,Cr (x=0.3) crystal under a Tm fiber 1940 nm laser pumping through a Cr→Fe energy transfer process for the first time, to the best of our knowledge. The laser slope efficiency was 1% with respect to absorbed pumping energy at 1940 nm.

High-throughput sequencing of T-cell receptor alpha chain clonal rearrangements at the DNA level in lymphoid malignancies.

Rearrangements of T- and B-cell receptor (TCR and BCR) genes are useful markers for clonality assessment as well as for minimal residual disease (MRD) monitoring during the treatment of haematological malignancies. Currently, rearrangements of three out of four TCR and all BCR loci are used for this purpose. The fourth TCR gene, TRA, has not been used so far due to the lack of a method for its rearrangement detection in genomic DNA.

Influence of the pumping wavelength on laser properties of Fe ions in ZnSe crystal.

ZnSe:Fe active laser crystal properties at different excitation wavelengths (2.94 and 4.1 μm) were investigated, and noticeable variations of the fluorescence spectra shape and their maxima positions, as well as changes in decay times, were observed.

Room temperature Fe:CdMnTe laser generating at 5.4-6 μm.

Six-μm laser generation at room temperature was achieved from Fe-doped CdMnTe solid-solution active media for the first time, to the best of our knowledge. Laser properties of Fe:CdMnTe crystals with various concentrations of manganese Mn (x=0.1, 0.

Comparison of Real-time Quantitative Polymerase Chain Reaction and Eight-color Flow Cytometry in Assessment of Minimal Residual Disease in Adult Acute Lymphoblastic Leukemia.

Background: Minimal residual disease (MRD) is an important prognostic maker in acute lymphoblastic leukemia (ALL). However, few data comparing the measurement of adult ALL MRD using different methods in daily practice are available. We conducted an analysis comparing the importance of flow cytometry (FCM) and real-time quantitative polymerase chain reaction (PCR) in the assessment of MRD in adult ALL.

Line-tunable Er:GGAG laser.

In this Letter, for the first time, to the best of our knowledge, a pulse and CW laser based on an Er-doped GdGaAlO (Er:GGAG) active medium emitting laser radiation at 2.8 μm are presented. With the longitudinal diode pumping, the maximal output energy of 4.

Low-Level Laser Therapy After Wisdom Teeth Surgery: Evaluation of Immunologic Markers (Secretory Immunoglobulin A and Lysozyme Levels) and Thermographic Examination: Placebo Controlled Study.

Objective: The goal of this investigation is to analyze the effect of therapeutic low-level laser therapy (LLLT) to have a possibility to check pain and inflammation connected with surgical removal of impacted lower third molars in general anesthesia or even phobia [not accompanied by pain or fear of dental treatment, using immunologic markers-secretory immunoglobulin A (sIgA) and lysozyme]. The healing process was also monitored by infrared thermography.

Background Data: LLLT can accelerate the proliferation phase of healing and decrease the inflammatory reaction, but the effect is not really clear.

Thulium fiber pumped tunable Ho:CaF laser.

The paper reports the first room-temperature operation of the in-band pumped Ho:CaF laser. A set of Ho:CaF crystals varying in holmium concentrations (from 0.1 up to 2.

Spectroscopic and laser properties of bulk iron doped zinc magnesium selenide Fe:ZnMgSe generating at 4.5 - 5.1 µm.

The Fe:Zn(1-x)Mg(x)Se (x = 0.19, 0.27, and 0.

The Use of the Er:YAG Laser for Bracket Debonding and Its Effect on Enamel Damage.

Objective: The aim of the study was to evaluate the influence of Er:YAG laser irradiation on the debonding of metal and ceramic brackets and enamel damage ex vivo.

Background Data: The principle of safe bracket debonding is to degrade the adhesive resin strength connecting the tooth and bracket. Removal of adhesive resin from tooth surfaces without iatrogenic damage (enamel loss) is generally the main problem of the otherwise very successful method of aesthetic straightening of teeth.

Comparison of quality of facial scars after single low-level laser therapy and combined low-level with high-level (PDL 595 nm) laser therapy.

The main goal of our study was to compare the quality of resulting facials scar 12 weeks after single and combined laser therapy. Forty-one children from age 1.5 to 5 years with facial scars after injury participated in the study.

2-μm wavelength, high-energy Ho:YLF chirped-pulse amplifier for mid-infrared OPCPA.

A 2-μm wavelength laser delivering up to 39-mJ energy, ∼10  ps duration pulses at 100-Hz repetition rate is reported. The system relies on chirped pulse amplification (CPA): a modelocked Er:Tm:Ho fiber-seeder is followed by a Ho:YLF-based regenerative amplifier and a cryogenically cooled Ho:YLF single pass amplifier. Stretching and compressing are performed with large aperture chirped volume Bragg gratings (CVBG).