Nowadays, with the development of electromobility, the requirements not only for the mechanical properties but also for the thermal conductivity of castings are increasing. This paper investigates the influence of casting and heat treatment technology on the thermal diffusivity and thermal conductivity of an AlSi10MnMg alloy. The thermal diffusivity was monitored as a function of temperature in the range of 50-300 °C for the material cast by high-pressure die casting (HPDC) and also by gravity sand casting (GSC) and gravity die casting (GDC).
View Article and Find Full Text PDFCancers (Basel)
September 2024
Mucosal melanoma of the head and neck (HNMM) is a rare but highly aggressive malignancy, often diagnosed at an advanced stage with poor prognosis. This review discusses current treatment strategies, emphasizing the role of radiotherapy in managing this challenging disease. A comprehensive analysis of 33 studies provides updated information on techniques and outcomes, highlighting the consistent benefit of adjuvant radiation in improving local control.
View Article and Find Full Text PDFBackground: Peritoneal metastases due to gastric adenocarcinoma (GCPM) carry a dismal prognosis. A promising treatment strategy is cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), but clear eligibility criteria for GCPM are lacking. We sought to identify factors associated with overall survival (OS) following CRS-HIPEC for GCPM to help optimize patient selection and clinical outcomes.
View Article and Find Full Text PDFWe tested the effect of substituents at the (1) C3´, C3´N, (2) C10, and (3) C2-meta-benzoate positions of taxane derivatives on their activity against sensitive versus counterpart paclitaxel-resistant breast (MCF-7) and ovarian (SK-OV-3) cancer cells. We found that (1) non-aromatic groups at both C3´ and C3´N positions, when compared with phenyl groups at the same positions of a taxane derivative, significantly reduced the resistance of ABCB1 expressing MCF-7/PacR and SK-OV-3/PacR cancer cells. This is, at least in the case of the SB-T-1216 series, accompanied by an ineffective decrease of intracellular levels in MCF-7/PacR cells.
View Article and Find Full Text PDFBackground: Normal carcinoembryonic antigen (CEA) levels (≤ 2.5 ng/ml) after resection of localized colorectal cancer or liver metastases are associated with improved survival, however, these trends are understudied for colorectal peritoneal metastases (CRPM).
Patients And Methods: We conducted a retrospective single-institution study of patients with CRPM undergoing cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (CRS/HIPEC) with and without neoadjuvant chemotherapy (NACT).
Introduction: Early studies show conflicting findings regarding particulate matter ≤ 2.5 μm in diameter (PM) exposure and development of head and neck cancers (HNC). We analyzed the relationship between PM exposure and various types of HNC in a nationally representative ecological sample.
View Article and Find Full Text PDFStroke is a devastating cerebrovascular pathology with high morbidity and mortality. Inflammation plays a central role in the pathophysiology of stroke. Vagus nerve stimulation (VNS) is a promising immunomodulatory method that has shown positive effects in stroke treatment, including neuroprotection, anti-apoptosis, anti-inflammation, antioxidation, reduced infarct volume, improved neurological scores, and promotion of M2 microglial polarization.
View Article and Find Full Text PDFProper immobilization is critical for the delivery of high-quality radiation therapy. In cases when traditional immobilization is not feasible, 3-dimensional (3D) printing may provide a better-tolerated custom immobilization that is comparably effective. We present the successful treatment of a patient with inoperable oropharyngeal squamous cell carcinoma who was unable to tolerate traditional immobilization.
View Article and Find Full Text PDFBackground: We aim to describe outcomes of elderly patients undergoing salvage surgery for laryngeal cancer and to characterize the interplay of age with various other factors in this growing population.
Methods: Using the National Cancer Database, we identified cases of salvage laryngectomy in patients who failed chemoradiation. An age cutoff of 70 years was used to separate subjects into two groups.
Patients with tumors that do not respond to immune-checkpoint inhibition often harbor a non-T cell-inflamed tumor microenvironment, characterized by the absence of IFN-γ-associated CD8 T cell and dendritic cell activation. Understanding the molecular mechanisms underlying immune exclusion in non-responding patients may enable the development of novel combination therapies. p38 MAPK is a known regulator of dendritic and myeloid cells however a tumor-intrinsic immunomodulatory role has not been previously described.
View Article and Find Full Text PDFThe article introduces an original VR-based experiment which explores context-dependent memory recall in humans. It specifically examines the recall of correct and falsely induced semantic memories. With the aid of VR head-mounted displays, 92 students of psychology were placed in a computer-generated indoor virtual environment and asked to memorize the presented lists of words.
View Article and Find Full Text PDFCurr Treat Options Oncol
June 2023
Epidermal growth factor receptor (EGFR) is commonly overexpressed in many head and neck squamous cell carcinomas (HNSCC). With the success of EGFR inhibition in other cancer types, there was optimism for efficacy in HNSCC. Unfortunately, the clinical outcomes of EGFR-directed therapy have not provided overwhelming benefit.
View Article and Find Full Text PDFA limited number of studies are devoted to regulating expression in cancer. Hence, we aimed to unveil the regulation of expression in MCF-7 breast cancer cells (with high expression) and taxane-resistant MCF-7 sublines (manifesting even higher expression). We found that transcription is regulated primarily by the cyclic AMP response element (CRE) in hypomethylated proximal promoters in both taxane-sensitive and taxane-resistant MCF-7 cells.
View Article and Find Full Text PDFThe ability of materials to withstand environmental influences is a frequent necessity in many industries. Special requirements are imposed by such industries where surfaces are affected by acidity during the processing or storage of products. In such cases, when the basic surface is exposed to chemical influences, it is possible to use enamel coatings, which, with their properties, guarantee the protection of the surface and achieve the required service life of the material.
View Article and Find Full Text PDFBackground: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed consensus treatment plans (CTPs) to compare treatment initiation strategies for systemic juvenile idiopathic arthritis (sJIA). First-line options for sJIA treatment (FROST) was a prospective observational study to assess CTP outcomes using the CARRA Registry.
Methods: Patients with new-onset sJIA were enrolled if they received initial treatment according to the biologic CTPs (IL-1 or IL-6 inhibitor) or non-biologic CTPs (glucocorticoid (GC) monotherapy or methotrexate).
Introduction With the incorporation of modernized radiotherapy, chemotherapy, and immunotherapy, treatment outcomes have improved for patients with locally advanced, unresectable diseases. Elderly or poor performance status patients comprise more than half of non-small cell lung cancer (NSCLC) patients, but they are often underrepresented or excluded in clinical trials. Split-course concurrent chemoradiotherapy can be an effective treatment, showing good adherence and a favorable toxicity profile for unresectable, locally advanced NSCLC.
View Article and Find Full Text PDFBackground/aim: There is significant variation in post-treatment surveillance imaging for sinonasal malignancies. This study examined the utility of surveillance imaging in detecting recurrence in patients treated for sinonasal malignancies.
Patients And Methods: We performed a retrospective review on an IRB-approved dataset of patients with sinonasal malignancies treated at a single institution between 2005 to 2021.
Cent Eur J Public Health
September 2022
Objective: This study aimed to assess the relative load of the midfoot and the metatarsals of both feet when schoolchildren walked with backpacks of different loads.
Methods: A group of 12 healthy girls (9.9 ± 0.
In nuclear power plants, particle accelerators, and other nuclear facilities, measuring the level of ionising gamma radiation is critical for the safety and management of the operation and the environment's protection. However, in many cases, it is impossible to monitor ionising radiation directly at the required location continuously. This is typically either due to the lack of space to accommodate the entire dosimeter or in environments with high ionising radiation activity, electromagnetic radiation, and temperature, which significantly shorten electronics' lifetime.
View Article and Find Full Text PDFPediatric cancer can be considered an event potentially leading to posttraumatic stress symptoms (PTSS) as well as posttraumatic growth (PTG). While clinically significant levels of PTSS are rare in childhood cancer survivors, PTG is common in this population. However, the relationship of PTG to overall adaptation and quality of life (QOL) in pediatric cancer patients is not clear.
View Article and Find Full Text PDFWe investigated the use of crystalline coatings as the highly reflective coating of an Yb:YAG thin disk directly bonded onto a silicon carbide heatsink. Compared to commonly used ion-beam-sputtered coatings, it possesses lower optical losses and higher thermal conductivity, resulting in better heat management and laser outputs. We pumped the disk up to 1.
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