Publications by authors named "Jelena Kosaric"
Article Synopsis
- A series of novel tryptamine-derived Schiff bases was synthesized to explore new pharmacological properties, leveraging the indole pharmacophore.
- TSB4 exhibited superior antifungal activity compared to the standard drug Fluconazole, while TSB6 demonstrated cytotoxic effects on HCT-116 cancer cells with selectivity for healthy fibroblast cells.
- Additional analysis showed strong binding to CT-DNA and favorable ADME properties, indicating potential for oral bioavailability and drug-like characteristics.
A Machine Learning Approach to Gene Expression in Hypertrophic Cardiomyopathy.
Pharmaceuticals (Basel)
October 2024
Article Synopsis
- Hypertrophic cardiomyopathy (HCM) is a heart condition marked by thickening of the heart muscle, heightening the risk for serious heart issues, and this study looks into the expression of certain genes related to cell death (apoptosis) as potential markers for the disease's progression.
- Blood samples from 93 HCM patients were analyzed using quantitative real-time PCR (qPCR) to assess gene expression and study the relationship between these genes and clinical parameters.
- Results showed that many HCM patients had lower levels of specific apoptosis-regulating genes, whereas BAX and another gene were elevated in a significant number of cases, indicating a possible protective response in the heart, which may be explored further for improving treatment outcomes
Article Synopsis
- Pharmacological agents with antioxidant properties play a crucial role in preventing and treating health issues linked to oxidative stress, such as cancer.
- A study assessed 14 new compounds called N-pyrocatechoyl and N-pyrogalloyl hydrazones (N-PYRs), revealing their strong ability to neutralize harmful free radicals and their beneficial antioxidant pathways.
- Further analysis showed that four of these compounds selectively targeted cancer cells while also demonstrating antibacterial effects, indicating their potential as effective antioxidant agents with dual therapeutic applications.
Selenium and palladium containing compounds separately exert multifunctional effects on cells. While selenium containing compounds usually exert antioxidative properties, palladium(II) containing compounds are cytotoxic and prooxidative. Here we investigated biological effects of bicyclic seleno-hydantoin cis-7a-ethyl-5-methyl-5-phenylselanylmethyl-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione (Hid-Se), and its palladium(II) complex, trans-bis-(cis-7a-ethyl-5-methyl-5-phenylselanylmethyl-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dionato) palladium(II) chloride ((Hid-Se)2Pd) on human colon HCT-116 and breast MDA-MB-231 cancer cell lines.
View Article and Find Full Text PDFPurpose: To determine the antioxidant and antiproliferative influence of 2-(phenylselenomethyl)tetrahydrofuran (1a) and 2-(phenylselenomethyl)tetrahydropyran (2a) on colon cancer cell line HCT-116 and breast cancer cell line MDA-MB-231.
Methods: Cell viability was monitored in a dose-dependent manner using MTT assay. The concentration of superoxide anion radical (O2 •(-)) was determined spectrophotometrically.