The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1.

Herpes simplex virus 1 (HSV-1) expresses a large number of miRNAs, and their function is still not completely understood. In addition, HSV-1 has been found to deregulate host miRNAs, which adds to the complexity of the regulation of efficient virus replication. In this study, we comprehensively addressed the deregulation of host miRNAs by massive-parallel sequencing.

MR-compatible treadmill for exercise stress cardiac magnetic resonance imaging.

This article describes an MR-safe treadmill that enables cardiovascular exercise stress testing adjacent to the MRI system, facilitating cardiac MR imaging immediately following exercise stress. The treadmill was constructed of nonferromagnetic components utilizing a hydraulic power system. Computer control ensured precise execution of the standard Bruce treadmill protocol commonly used for cardiovascular exercise stress testing.

A new approach to autocalibrated dynamic parallel imaging based on the Karhunen-Loeve transform: KL-TSENSE and KL-TGRAPPA.

TSENSE and TGRAPPA are autocalibrated parallel imaging techniques that can improve the temporal resolution and/or spatial resolution in dynamic magnetic resonance imaging applications. In its original form, TSENSE uses temporal low-pass filtering of the undersampled frames to create the sensitivity map. TGRAPPA uses a sliding-window moving average when finding the autocalibrating signals.

Magnetic field threshold for accurate electrocardiography in the MRI environment.

Although the electrocardiogram is known to be nondiagnostic within the bore of any high-field magnet due to the magnetohydrodynamic effect, there are an increasing number of applications that require accurate electrocardiogram monitoring of a patient inside the MRI room but outside of the magnet bore. Magnetohydrodynamic effects on the ST segment of the electrocardiogram waveform were investigated in six subjects at magnetic field strengths ranging from 6.4 mT to 652 mT at the aortic midarch, and the electrocardiogram was found to be accurate at magnetic fields below 70 mT.

Real-time cine and myocardial perfusion with treadmill exercise stress cardiovascular magnetic resonance in patients referred for stress SPECT.

Background: To date, stress cardiovascular magnetic resonance (CMR) has relied on pharmacologic agents, and therefore lacked the physiologic information available only with exercise stress.

Methods: 43 patients age 25 to 81 years underwent a treadmill stress test incorporating both Tc99m SPECT and CMR. After rest Tc99m SPECT imaging, patients underwent resting cine CMR.

Cardiac function and myocardial perfusion immediately following maximal treadmill exercise inside the MRI room.

Treadmill exercise stress testing is an essential tool in the prevention, detection, and treatment of a broad spectrum of cardiovascular disease. After maximal exercise, cardiac images at peak stress are typically acquired using nuclear scintigraphy or echocardiography, both of which have inherent limitations. Although CMR offers superior image quality, the lack of MRI-compatible exercise and monitoring equipment has prevented the realization of treadmill exercise CMR.

[The status of plate osteosynthesis in the treatment of femur shaft fracture in polytrauma patients].

In the frame of multiple injuries we had 30% of the fractures of the femur. We treated 113 patients with polytraumas with fractures of the femur and with the plate. We had 25% AIS grade 1, 48% AIS grade 2, 21% AIS grade 3 and 6% AIS grade 4.

[Acute abdomen in the elderly].

From 1984 to 1992 we treated 4341 patients with acute abdominal disease in the elderly. We divided all patients in two groups. In the first group were all patients up to 60 years; in the second group all patients above 60 years.

[Primary management and problems with osteosynthesis of subtrochanteric fractures of the femur].

From 1986 to 1991 we treated 63 patients with subtrochanteric fracture of the femur. The etiology in 53 patients with 40 fractures mostly pedestrians, hit by a car; or motor vehicle accidents, in other words high velocity injuries that resulted in a significant number of multiply injured patients of whom 38 were polytraumatized, by our definition a multiply injured person with a life threatening injury of at least one of the following body parts: head, neck, thorax, abdomen, spine, extremities with neurovascular compromise and pelvic girdle.

[Effect of chemotherapy on survival in advanced breast cancer].

Survival time of 119 consecutive patients with metastasizing carcinoma of the breast who had been treated with various chemotherapeutic schedules after radical operation was determined retrospectively. 57 women received chemotherapy and hormones, as well as radiotherapy, while 62 had radiotherapy plus hormone treatment. The mean prolongation of life in the former group over that of the latter was 12 months (p less than 0.

[Polytrauma with retroperitoneal injuries].

From 1971-1987, 598 polytraumatized patients had concomitant injuries of the retroperitoneal space. The mortality rate came up to 33.4%.

[Primary clinical experience with heterotopic autologous transplantation of the spleen].

On the basis of research and results obtained in recent years that the removing of the spleen increases an aptitude to the infection, the authors have carried out in 1981-1982 four autotransplantations of the spleen; they did it in polytraumatised patients with an extensive rupture of the spleen, where, because of the safe haemostasis, only a splenectomy should have to be performed. By a new technique, removed ruptured spleen is prepared with special procedure, and it is transplanted into the omentum majus of the same patient. There were no complications, although it is concerned of a few patients and a short postoperative follow-up.

[Traumatic intestinal infarction].

A study of 31 cases of traumatic intestinal infarction, often old cases, did not show any characteristic clinical picture or course but showed the following points: abdominal contusion, even mild, may induce intestinal infarction; the ileum and ascending colon are most commonly involved, and infarction usually follows a thrombosis of the mesenteric veins; the clinical course usually includes an interval between the trauma and the infarction.

[Superficial cancer of the stomach in our hospital].

Gastric cancer remains difficult to cure except in its superficial spreading stage, that is when it is mucosal or submucosal without any lymph node involvement. Its detection rate should reach 20% of all cancers. Three anatomical types are described: the malignant polyp, the muco-erosive cancer and the ulcero-cancer.

[Osteomyelitis after osteosynthesis].

In reparative surgery, and particularly reosteo-synthesis, latent or apathogenic germ invasion of "old" wounds must always be reckoned with. Antiinfectious measures, which must be pursued untiringly, are to be placed beside equivalent surgical measures which should go beyond mere operative care of traumatic tissue damage.