Hematopoietic stem cell transplant research with pediatric donors: when can institutional review boards approve it?

Although pediatric donation of hematopoietic stem cells (HSCs) for allogeneic transplants is common in the clinical setting, the question of when children may donate HSCs in research has received little attention. Our analysis reveals that institutional review boards (IRBs) may approve children's participation as HSC donors in transplant research when it poses no more than minimal risk to them. The risks that IRBs should consider are those that result specifically from the research, as opposed to risks donors would have faced regardless of the research.

Delivery room decision-making for extremely preterm infants in Sweden.

Objective: To assess neonatologists' attitudes and practices regarding treatment of extremely preterm infants in the delivery room, particularly in response to parental wishes.

Study Design: Cross-sectional survey of all neonatologists in Sweden registered with the Swedish Pediatric Society.

Results: The response rate was 71% (88 of 124 neonatologists).

Delivery room decision-making at the threshold of viability.

Objectives: To assess attitudes of neonatologists toward parental wishes in delivery room resuscitation decisions at the threshold of viability.

Study Design: Cross-sectional survey of the 175 practicing level II/III neonatologists in six New England states.

Results: Response rate was 85% (149/175).