Background Benign prostatic hyperplasia (BPH) is a prevalent condition that a large portion of the male population develops with aging, in which the prostate gland enlarges and results in urinary symptoms. Objective The objective of this article is to assess patient-reported outcomes (PRO) of medical management of benign prostate hyperplasia in terms of international prostate symptoms score (IPSS), BPH impact index (BPHII), and treatment satisfaction score (TSS). Methods This descriptive study included 114 patients who received medical management for BPH during the period 5 May 2021 till 30 December 2023, at the Department of Urology, Institute of Kidney Disease Peshawar.
View Article and Find Full Text PDFAbdominal aortic aneurysm (AAA) is a life-threatening vascular disease, while there is a lack of pharmaceutical interventions to halt AAA progression presently. To address the multifaceted pathology of AAA, this work develops a novel multifunctional gene delivery system to simultaneously deliver two siRNAs targeting MMP-2 and MMP-9. The system (TPNs-siRNA), formed through the oxidative polymerization and self-assembly of epigallocatechin gallate (EGCG), efficiently encapsulates siRNAs during self-assembly.
View Article and Find Full Text PDFContamination of aquatic and terrestrial environment with hexavalent chromium Cr(VI) is one of the major hazards worldwide due its carcinogenicity, persistency and immobility. Different research techniques have been adopted for Cr(VI) remediation present in terrestrial and aquatic media, while adsorption being the most advance, low cost, environmentally friendly and common method. The present study discussed the mechanisms of Parthenium hysterophorus derived biochar, iron-doped zinc oxide nanoparticles (nFe-ZnO) and Fe-ZnO modified biochar (Fe-ZnO@BC) involved in Cr(VI) mobility and bioavailability.
View Article and Find Full Text PDFResearch (Wash D C)
January 2024
Photodynamic therapy (PDT) has emerged as a promising approach for squamous cell carcinoma treatment but hindered by tumor hypoxia, acquired resistance, phototoxicity, and so on. To address these issues, we developed a smart strategy utilizing activable photosensitizers delivered by an aptamer-functionalized DNA probe (ADP). The ADP incorporated an AS1411 aptamer for tumor targeting and a linear antisense oligonucleotide (ASO) for recognition of Survivin mRNA.
View Article and Find Full Text PDFBACKGROUND Acute back pain is common in primary care settings (>60% lifetime prevalence). Patients can also have associated red flag signs, such as fever, spinal tenderness, and neurologic deficits, that warrant further evaluation and investigation to optimize diagnosis and treatment. CASE REPORT A 70-year-old man with a history of benign prostatic hyperplasia and hypertension sought care for midthoracic back pain.
View Article and Find Full Text PDFIn this study we investigated the efficacy of a novel material parthenium weed ( L.) biochar (PBC), iron doped zinc oxide nanoparticles (Fe-ZnO), and biochar modified with Fe-ZnO (Fe-ZnO@BC) to adsorb heavy metals (HMs) and reduce their uptake by wheat ( L.) in a highly chromite mining contaminated soil.
View Article and Find Full Text PDFPolydatin (PD) is a natural compound with anticancer activities, but the underlying mechanisms remain largely unclear. To understand how PD inhibited hepatocellular carcinoma (HCC), we studied PD treatments in HCC HepG2 and SK-HEP1 cells, and normal liver HL-7702 cells. PD selectively blocked the proliferation of HCC cells but showed low toxicity in normal cells, while the effects of doxorubicin (DOX) and cisplatin (DDP) on HCC and normal liver cells were opposite.
View Article and Find Full Text PDFThe present study is aimed to investigate the hydrochemical characteristics, spatial distribution and suitability of groundwater for drinking and irrigation purposes along the Indus Suture Zone (ISZ), north Pakistan. Physicochemical parameters and hazardous trace elements (HTEs) like Cd, Co, Cu and Mn were determined following standard methods. The mean and median concentrations were found below the World Health Organization (WHO) drinking water guidelines values.
View Article and Find Full Text PDFArsenic trioxide (ATO) is one of the first-line chemotherapeutic drugs for acute promyelocytic leukemia. Its anti-cancer activities against various human neoplastic diseases have been extensively studied. However, the clinical use of ATO for solid tumors is limited, and these limitations are because of severe systemic toxicity, low bioavailability, and quick renal elimination before it reaches the target site.
View Article and Find Full Text PDFBackground: Most chemotherapeutics used in cancer therapies exhibit considerable side effects to the patients. Thus, developing new chemo agents to treat cancer patients with minimal toxic and side effects is urgently needed. Recently, the combination of different chemotherapeutics has become a promising strategy to treat malignancies.
View Article and Find Full Text PDFJ Ayub Med Coll Abbottabad
November 2021
Distal radius fractures are very common injuries. Majority of these fractures are transverse or oblique in nature. Isolated vertical fractures of the distal radius in the sagittal plane are rare injuries.
View Article and Find Full Text PDFBiochim Biophys Acta Gen Subj
July 2021
Background: Ellagic acid (EA) possesses prominent inhibitory activities against various cancers, including hepatocellular carcinoma (HCC). Our recent study demonstrated EA's activities in reducing HCC cell proliferation and tumor formation. However, the mechanisms of EA to exert its anticancer activities and its primary targets in cancer cells have not been systematically explored.
View Article and Find Full Text PDFPurpose: To analyze hepatobiliary specific contrast agent (HBA) dynamic MRI signal intensity (SI) differences between treated liver (TL) and untreated liver (UL) parenchyma in patients following transarterial radioembolization (TARE) for hepatocellular carcinoma (HCC) using yttrium-90 containing glass microspheres.
Materials: This was a single institution retrospective study of patients with HCC treated with lobar or segmental TARE who received pre- and post-treatment HBA multiphase MRI within a 3-year period. Patients with prior locoregional therapies or multiple TAREs were excluded.
Thymoquinone (TQ) is a natural compound extracted from the black seeds of Linn. belonging to the Ranunculaceae family. TQ exhibits anti-inflammatory and antineoplastic activities against various cancers.
View Article and Find Full Text PDFThis study evaluates the characteristics of water along the Swat River, Northern Pakistan. For this purpose, water samples (n = 30) were collected and analyzed for physicochemical parameters including heavy metals (HM). The mean concentrations of physicochemical parameters and HM were within the drinking water guideline values set by the World Health Organization (WHO 2011) except 34%, 60%, and 56% of copper (Cu), nickel (Ni), and lead (Pb), respectively.
View Article and Find Full Text PDFWe performed a systematic review to find out the safety and efficacy of various procedures for isolated scaphotrapeziotrapezoid osteoarthritis. Eleven articles were included. The most common procedure was arthroplasty with pyrocarbon implant (28%), followed by resection of distal pole of scaphoid with proximal trapezium and trapezoid resection (18%).
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
January 2020
This study aimed to investigate the contamination of drinking water sources with potentially toxic metals (PTMs) together with some hydrochemical characteristics in the highly populated industrial zone of Pakistan. For this purpose, drinking (n = 40) and surface (n = 20) water samples were collected and analyzed for PTM using graphite furnace atomic absorption spectrophotometer (GFAAS, PerkinElmer-700, USA). The metals, including cadmium (Cd), chromium (Cr), nickel (Ni), lead (Pb), and zinc (Zn), showed significantly (p = 0.
View Article and Find Full Text PDFBackground: Hip fractures are common with a UK incidence of over 70,000 cases and total healthcare costs of over £2 billion per year. Mortality rates of 10% at 30 days and up to 30% at 1-year have been reported. We wanted to assess the outcome of hip fracture surgery in patients with reduced pre-fracture mobility as this has not been exclusively studied previously.
View Article and Find Full Text PDFThe study aimed to assess the physicochemical parameters (pH, electrical conductivity (EC), total dissolve solid (TDS), oxidation reduction potential (ORP), Temperature) and potential toxic metals (PTMs), including Ni, Mn, Cr, Cu, Cd, Pb, Co, Fe and Zn in the groundwater of Lower Dir, Pakistan. Furthermore, the pollution sources and spatial distribution pattern of PTMs were also investigated via principal component analysis (PCA) and geographic information system (GIS) application to understand the changing behaviors of PTMs in groundwater. The average concentrations of physicochemical parameters such as pH, EC, TDS, ORP and Temperature were 7.
View Article and Find Full Text PDFPurpose: To retrospectively analyze adverse events (AE) in patients with hepatocellular carcinoma (HCC) treated with yttrium-90 radioembolization in the setting of angiographically apparent arterioportal shunts (APSs).
Materials And Methods: Thirty-two patients with HCC underwent radioembolization with APSs from January 2011 to September 2016, totaling 34 administrations using resin (6) and glass (28) microspheres. APSs were graded angiographically as segmental (9), ipsilobar (15), contralobar (7), or main portal (2), according to portal perfusion.
Environ Sci Pollut Res Int
October 2018
The present study was conducted on soft drink industry with the objective to reduce wastewater pollution through end-of-pipe treatment and controlling energy loss through steam pipeline insulation approach. For this purpose, the main operation and manufacturing steps were examined. Wastewater was analyzed for 10 physicochemical parameters.
View Article and Find Full Text PDFPurpose: To evaluate the efficacy and safety of transarterial yttrium-90 glass microsphere radioembolization in patients with unresectable intrahepatic cholangiocarcinoma (ICC).
Materials And Methods: Retrospective review of 85 consecutive patients (41 men and 44 women; age, 73.4 ± 9.
Background: Surgical resection is the standard of care for intrahepatic cholangiocarcinoma (ICC), but only a minority of patients are managed surgically. Other modalities, including external beam radiation (XRT), radiofrequency ablation (RFA), and radioactive implants (RIs) have been employed with significant heterogeneity of prognosis reported in the literature. The aim of this study was to evaluate the demographics of patients with ICC managed non-surgically and compare prognosis in patients managed surgically to those that underwent XRT, RFA, or RI.
View Article and Find Full Text PDFThis study investigated the fluoride (F) concentrations and physicochemical parameters of the groundwater in a fluorite mining area of the flood plain region of the River Swat, with particular emphasis on the fate and distribution of F and the hydrogeochemistry. To better understand the groundwater hydrochemical profile and F enrichment, groundwater samples (n=53) were collected from shallow (24-40m), mid-depth (48-65m) and deep (85-120m) aquifers, and then analysed using an ion-selective electrode. The lowest F concentration (0.
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