Role of calcineurin biosignaling in cell secretion and the possible regulatory mechanisms.

Cyclic adenosine monophosphate (cAMP) and calcium ions (Ca) are two chemical molecules that play a central role in the stimulus-dependent secretion processes within cells. Ca acts as the basal signaling molecule responsible to initiate cell secretion. cAMP primarily acts as an intracellular second messenger in a myriad of cellular processes by activating cAMP-dependent protein kinases through association with such kinases in order to mediate post-translational phosphorylation of those protein targets.