Advanced Unresectable Differentiated Thyroid Cancer With Anaplastic Transformation: A Case Report and Review of the Literature.

Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer (TC). Although surgery and radioactive iodine therapy (RAI) generally yield favorable outcomes, advanced cases with extensive local invasion and metastases pose significant challenges. We report the case of a 65-year-old male with advanced, inoperable PTC characterized by extensive local invasion and distant metastases.

An Incidental Finding of Concomitant Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma: A Case Report.

Concomitant medullary thyroid carcinoma and papillary thyroid carcinoma in the thyroid gland are rare; however, the incidence is increasing. Here, we present the case of a 77-year-old male who was incidentally found to have thyroid nodules after a road traffic accident. Fine-needle aspiration revealed two inconclusive Bethesda classifications: follicular neoplasm and unsatisfactory.

Ipsilateral Foot Drop After Leg Traction on Fracture Table for Mid-Shaft Femur Fracture Nailing: A Rare Case Report.

Femoral shaft fracture, one of the most common orthopaedic injuries, is usually treated with intramedullary nailing. During the operative procedure patients are placed on a traction table. Traction tables facilitate the procedure but are associated with some risk.

VelcroVax: a "Bolt-On" Vaccine Platform for Glycoprotein Display.

Having varied approaches to the design and manufacture of vaccines is critical in being able to respond to worldwide needs and newly emerging pathogens. Virus-like particles (VLPs) form the basis of two of the most successful licensed vaccines (against hepatitis B virus [HBV] and human papillomavirus). They are produced by recombinant expression of viral structural proteins, which assemble into immunogenic nanoparticles.

Structural insight into Pichia pastoris fatty acid synthase.

Type I fatty acid synthases (FASs) are critical metabolic enzymes which are common targets for bioengineering in the production of biofuels and other products. Serendipitously, we identified FAS as a contaminant in a cryoEM dataset of virus-like particles (VLPs) purified from P. pastoris, an important model organism and common expression system used in protein production.

Inflammatory and immunometabolic consequences of gut dysfunction in HIV: Parallels with IBD and implications for reservoir persistence and non-AIDS comorbidities.

The gastrointestinal mucosa is critical for maintaining the integrity and functions of the gut. Disruption of this barrier is a hallmark and a risk factor for many intestinal and chronic inflammatory diseases. Inflammatory bowel disease (IBD) and HIV infection are characterized by microbial translocation and systemic inflammation.