The mGlu2/3 agonist LY379268 reduces sucrose taking, seeking, and motivation in male and female rats.

Objectives: The mGlu2/3 receptor agonist LY379268 reduces sucrose-seeking, but not sucrose-taking, in male rats. This study explored the generality of this effect across the sexes. In addition, the effect of the drug on motivation to receive sucrose was assessed.