Publications by authors named "Jeffrey W Wertz"
Activation of bone morphogenetic protein (BMP) receptor II (BMPRII) promotes pulmonary artery endothelial cell (PAEC) survival, proliferation, and migration. Mutations to BMPRII are associated with the development of pulmonary arterial hypertension (PAH). Endothelial dysfunction, including decreased endothelial nitric-oxide synthase (eNOS) activity and loss of bioactive nitric oxide (NO), plays a prominent role in the development of PAH.
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- Fatty acid nitroalkenes are products of inflammatory processes that may help reduce inflammation by modifying proteins and activating genes.
- This study investigated whether a synthetic nitroalkene, nitro-oleic acid, could reduce inflammation in a mouse model of vascular injury.
- Findings showed that nitro-oleic acid treatment decreased neointimal hyperplasia by increasing the expression of heme oxygenase-1, which was crucial for its anti-inflammatory effects.
Caveolin-1 regulates BMPRII localization and signaling in vascular smooth muscle cells.
Biochem Biophys Res Commun
October 2008
Recent studies demonstrate the interaction of BMPRII and caveolin-1 in various cell types. In this study we test the hypothesis that caveolin-1 interacts with and regulates BMPRII-dependent signaling in vascular smooth muscle cells. We demonstrate that BMPRII localizes to caveolae and directly interacts with caveolin-1 in mouse aortic smooth muscle cells.
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