Publications by authors named "Jeffrey W Olin"
Article Synopsis
- Fibromuscular dysplasia (FMD) is a rare condition mostly affecting women, characterized by various arterial problems that can lead to serious health issues like hypertension and stroke.* -
- This study used genetic data from FMD patients and healthy controls to identify 18 gene regulatory networks, with four forming an FMD-related supernetwork affecting arterial health.* -
- By disrupting this supernetwork in mice, researchers observed symptoms of FMD, revealing insights into the disease's mechanisms and potential new treatment options.*
Article Synopsis
- * A large study identified 16 genetic risk factors for SCAD, highlighting potential genes involved in blood vessel function and the physical structure of arteries.
- * Some genetic variants linked to SCAD show opposing effects on CAD, suggesting that while both diseases share certain biological links, they operate through different pathways; high blood pressure was also found to possibly contribute to SCAD risk.
Inflammatory aortitis is most often caused by large vessel vasculitis (LVV), including giant cell arteritis, Takayasu's arteritis, immunoglobulin G4-related aortitis, and isolated aortitis. There are distinct differences in the clinical presentation, imaging findings, and natural history of LVV that are important for the cardiovascular provider to know. If possible, histopathologic specimens should be obtained to aide in accurate diagnosis and management of LVV.
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- Mitral valve prolapse and aortic root dilatation are common in people with hypermobile Ehlers-Danlos syndrome (hEDS), but the range of cardiovascular issues has not been fully explored until now.
- A study reviewing 258 patients diagnosed with hEDS or hypermobility spectrum disorder (HSD) found mitral valve prolapse in 7.5% and thoracic aortic dilatation in 15.2%, with higher rates in those with hEDS.
- Most cardiovascular symptoms were mild, especially in women, but patients with aortic dilatation need ongoing monitoring, and healthcare providers should include hEDS/HSD when evaluating patients with specific arterial complications like cervical artery dissection or spontaneous
Background The promise of precision population health includes the ability to use robust patient data to tailor prevention and care to specific groups. Advanced analytics may allow for automated detection of clinically informative subgroups that account for clinical, genetic, and environmental variability. This study sought to evaluate whether unsupervised machine learning approaches could interpret heterogeneous and missing clinical data to discover clinically important coronary artery disease subgroups.
View Article and Find Full Text PDFVascular Ehlers-Danlos syndrome is caused by mutations in the COL3A1 (collagen type III alpha-1) gene, resulting in loss of integrity of arteries and hollow organs. Patients are predisposed to dissection, aneurysm, and organ rupture. The median life expectancy is ∼51 years.
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- Fibromuscular dysplasia (FMD) is a condition that primarily affects women and can lead to serious health issues like hypertension and strokes; recent research involved a large study comparing FMD cases with controls.
- The study identified a genetic basis for FMD, discovering several significant gene loci linked to the disease that are involved in arterial cell functions and vascular contraction.
- Additionally, there is a notable genetic connection between FMD and other common cardiovascular conditions, suggesting shared underlying mechanisms across these diseases.
Article Synopsis
- * The TRA 2°P-TIMI 50 trial indicated that statin use significantly lowered the occurrence of major adverse cardiovascular events (MACEs) and limb ischemic events among patients, with the combination of statin therapy and vorapaxar yielding the best outcomes.
- * Overall, the findings suggest that addressing both lipid levels through statins and thrombotic risk with medications like vorapaxar is essential to improve patient outcomes in those with peripheral artery disease.
Background Fibromuscular dysplasia (FMD) is a nonatherosclerotic arterial disease that has a variable presentation including pulsatile tinnitus (PT). The frequency and characteristics of PT in FMD are not well understood. The objective of this study was to evaluate the frequency of PT in FMD and compare characteristics between patients with and without PT.
View Article and Find Full Text PDFBackground Cervical artery dissection (CeAD) is a frequent manifestation of fibromuscular dysplasia (FMD). However, risk factors for CeAD are unknown. We investigated factors associated with CeAD in the ARCADIA (Assessment of Renal and Cervical Artery Dysplasia) registry.
View Article and Find Full Text PDFConsiderations for Patients With Peripheral Artery Disease During the COVID-19 Pandemic.
Clin Appl Thromb Hemost
April 2021
New York City was one of the epicenters of the COVID-19 pandemic. The management of peripheral artery disease (PAD) during this time has been a major challenge for health care systems and medical personnel. This document is based on the experiences of experts from various medical fields involved in the treatment of patients with PAD practicing in hospitals across New York City during the outbreak.
View Article and Find Full Text PDFFibromuscular dysplasia (FMD) is a non-atherosclerotic vascular disease that may involve medium-sized muscular arteries throughout the body. The majority of FMD patients are women. Although a variety of genetic, mechanical, and hormonal factors play a role in the pathogenesis of FMD, overall, its cause remains poorly understood.
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View Article and Find Full Text PDF2021 ACC/AHA/SVM/ACP Advanced Training Statement on Vascular Medicine (Revision of the 2004 ACC/ACP/SCAI/SVMB/SVS Clinical Competence Statement on Vascular Medicine and Catheter-Based Peripheral Vascular Interventions): A Report of the ACC Competency Management Committee.
J Am Coll Cardiol
February 2021