Publications by authors named "Jeffrey W Gu"
Article Synopsis
- * Researchers studied mitochondrial protrusions in rat and planarian brains using transmission electron microscopy and found that these protrusions mainly originate from the outer mitochondrial membrane.
- * Analysis showed that the number of mitochondrial protrusions and vesicles increases under mild cellular stress, suggesting a potential adaptive response; further studies are needed to clarify their role and functionality in neurons.
Serial-section electron microscopy such as FIB-SEM (focused ion beam scanning electron microscopy) has become an important tool for neuroscientists to trace the trajectories and global architecture of neural circuits in the brain, as well as to visualize the 3D ultrastructure of cellular organelles in neurons. In this study, we examined 3D features of mitochondria in electron microscope images generated from serial sections of four regions of mouse brains: nucleus accumbens (NA), hippocampal CA1, somatosensory cortex and dorsal cochlear nucleus (DCN). We compared mitochondria in the presynaptic terminals to those in the postsynaptic/dendritic compartments, and we focused on the shape and size of mitochondria.
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