Publications by authors named "Jeffrey W Degen"
Object: Despite recent evidence showing that convection-enhanced delivery (CED) of viruses and virus-sized particles to the central nervous system (CNS) is possible, little is known about the factors influencing distribution of these vectors with convection. To better define the delivery of viruses and virus-sized particles in the CNS, and to determine optimal parameters for infusion, the authors coinfused adeno-associated virus ([AAV], 24-nm diameter) and/or ferumoxtran-10 (24 nm) by using CED during real-time magnetic resonance (MR) imaging.
Methods: Sixteen rats underwent intrastriatal convective coinfusion with 4 microl of 35S-AAV capsids (0.
Article Synopsis
- The study aimed to evaluate the safe delivery of a tumor-targeting cytotoxin, IL13-PE, to the brainstem using convection-enhanced delivery while monitoring its distribution in real-time with Gd-albumin.
- Thirty rats and twelve primates were perfused with varying concentrations of IL13-PE, and no toxicity was observed in rats across doses, while primates experienced toxicity at the highest concentration.
- The results confirmed that IL13-PE can be safely delivered at therapeutic levels to the primate brainstem, and Gd-albumin serves as an effective tracer for tracking the distribution of IL13-PE in real-time.
Object: The authors conducted a study to assess safety, pain, and quality of life (QOL) outcomes following CyberKnife radiosurgical treatment of spinal tumors.
Methods: Data obtained in all patients with spinal tumors who underwent CyberKnife radiosurgery at Georgetown University Hospital between March 2002 and March 2003 were analyzed. Patients underwent examination, visual analog scale (VAS) pain assessment, and completed the 12-item Short Form Health Survey (SF-12) before treatment and at 1, 3, 6, 8, 12, 18, and 24 months following treatment.
Object: Convection-enhanced delivery (CED) can be used safely to perfuse regions of the central nervous system (CNS) with therapeutic agents in a manner that bypasses the blood-brain barrier (BBB). These features make CED a potentially ideal method for the distribution of potent chemotherapeutic agents with certain pharmacokinetic properties to tumors of the CNS. To determine the safety and efficacy of the CED of two chemotherapeutic agents (with properties ideal for this method of delivery) into the CNS, the authors perfused naive rats and those harboring 9L gliomas with carboplatin or gemcitabine.
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