Duloxetine in the prevention of relapse of major depressive disorder: double-blind placebo-controlled study.

Background: Relapse rates may be as high as 50% in people with major depressive disorder (MDD) previously treated to remission.

Aims: Duloxetine, an inhibitor of serotonin and noradrenaline reuptake that is licensed in Europe, the USA and elsewhere for the treatment of depressive episodes, was evaluated with regard to its efficacy, safety and tolerability in the prevention of relapse of MDD.

Method: Adult out-patients with MDD received duloxetine (60 mg daily) for 12 weeks (n=533).

Androgen receptor in the oviduct of the turtle, Trachemys scripta.

Circulating androgens reach high concentrations in females of some reptiles and amphibians. We are testing the hypothesis that androgens can act directly in female reptilian reproductive tissues, via the androgen receptor. In this study, we sought to determine if androgen receptors are present in the oviduct of the turtle, Trachemys scripta, using radioligand-binding assays and immunological assays.