Preregistered test of whether a virtual nose reduces cybersickness.

Recent findings suggest that adding a visual depiction of a nose to virtual reality displays (virtual nose) can reduce motion sickness. If so, this would be a simple intervention that could improve the experience of a variety of VR applications. However, only one peer-reviewed study has reported a benefit from a virtual nose, and the effect was observed in a single low-powered experiment.

Restricting the distribution of visual attention reduces cybersickness.

This study investigated whether increased attention to the central or peripheral visual field can reduce motion sickness in virtual reality (VR). A recent study found that increased attention to the periphery during vection was correlated with lower self-reported motion sickness susceptibility, which suggests that peripheral attention might be beneficial for avoiding cybersickness. We tested this experimentally by manipulating visual attention to central vs.

The influence of valence and motivation dimensions of affective states on attentional breadth and the attentional blink.

Affective state has been shown to affect attention, but the affective dimension responsible for attentional effects remains under debate. Some studies suggest that attentional effects depend on the valence dimension of the affective state. Others have proposed that attentional effects depend on the motivational intensity of the affective state.

Perception of object motion during self-motion: Correlated biases in judgments of heading direction and object motion.

This study investigated the relationship between perceived heading direction and perceived motion of an independently moving object during self-motion. Using a dual task paradigm, we tested whether object motion judgments showed biases consistent with heading perception, both across conditions and from trial to trial. Subjects viewed simulated self-motion and estimated their heading direction (Experiment 1), or walked toward a target in virtual reality with conflicting physical and visual cues (Experiment 2).

Non-spatial similarity can bias spatial distances in a cognitive map.

The cognitive map theory suggests the hippocampal-entorhinal system has a representation of space that encodes geometric properties. There is also evidence that the hippocampus plays a critical role in supporting declarative memory, and recent theories have hypothesized the mechanism for encoding space is the same as that for processing memory. If space is not represented independently, it might be influenced by non-spatial properties.

The experience of stereoblindness does not improve use of texture for slant perception.

Stereopsis is an important depth cue for normal people, but a subset of people suffer from stereoblindness and cannot use binocular disparity as a cue to depth. Does this experience of stereoblindness modulate use of other depth cues? We investigated this question by comparing perception of 3D slant from texture for stereoblind people and stereo-normal people. Subjects performed slant discrimination and slant estimation tasks using both monocular and binocular stimuli.

Dual processes underlie the effect of the Ebbinghaüs illusion on control of grasping.

Previous studies have shown that control of grasping is affected by the Ebbinghaüs illusion. However, there is debate about whether effects on grasping are solely due to the illusion or involve other processes. The aim of this study was to distinguish the influences of the size illusion and obstacle avoidance on control of grip aperture.

Different generalization of fast and slow visuomotor adaptation across locomotion and pointing tasks.

Sensorimotor adaptation can involve multiple learning processes with different time courses, and these processes may have different patterns of transfer. In this study, we tested how slow learning and fast learning transfer across tasks, and the specificity of transfer. We tested two natural goal-directed tasks: pointing and walking toward a visible target.

Multiple texture cues are integrated for perception of 3D slant from texture.

The projected image of a textured surface contains multiple texture cues to three-dimensional (3D) surface orientation. Previous studies have reported conflicting findings about the roles of various texture cues. We tested the influence of texture compression relative to other texture cues using a cue conflict paradigm.

Paired walkers with better first impression synchronize better.

This study measured automatic walking synchronization and how it associates with social impression. Previous studies discovered positive social consequence of motor synchrony with ecological paradigms (e.g.

Perception of 3D slant from textures with and without aligned spectral components.

The image of a textured surface provides multiple potential cues that could be used to perceive its 3D structure. When a surface texture has oriented structure, perspective convergence of the oriented components provides a texture cue, in addition to texture scaling and compression. Some findings suggest that oriented spectral components aligned with the direction of slant are important for 3D perception from texture, but this has only been demonstrated in restricted situations.

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers.

Somatic point mutations at a key arginine residue (R132) within the active site of the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) confer a novel gain of function in cancer cells, resulting in the production of d-2-hydroxyglutarate (2-HG), an oncometabolite. Elevated 2-HG levels are implicated in epigenetic alterations and impaired cellular differentiation. IDH1 mutations have been described in an array of hematologic malignancies and solid tumors.

Volitional and automatic control of the hand when reaching to grasp objects.

When picking up an object, we tend to grasp at contact points that allow a stable grip. Recent studies have demonstrated that appropriate grasp points can be selected during an ongoing movement in response to unexpected perturbations of the target object. In this study, we tested whether such online grip adjustments are automatic responses or can be controlled volitionally.

AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic Mutations.

Somatic gain-of-function mutations in isocitrate dehydrogenases () 1 and 2 are found in multiple hematologic and solid tumors, leading to accumulation of the oncometabolite ()-2-hydroxyglutarate (2HG). 2HG competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone demethylases and methylcytosine dioxygenases of the TET family, causing epigenetic dysregulation and a block in cellular differentiation. studies have provided proof of concept for mutant IDH inhibition as a therapeutic approach.

Earliest Evidence of Toxocara sp. in a 1.2-Million-Yr-Old Extinct Hyena (Pachycrocuta brevirostris) Coprolite from Northwest Pakistan.

The study of fossil parasites can provide insight into the antiquity of host-parasite relationships and the origins and evolution of these paleoparasites. Here, a coprolite (fossilized feces) from the 1.2-million-yr-old paleontological site of Haro River Quarry in northwestern Pakistan was analyzed for paleoparasites.

Automatic adjustments toward unseen visual targets during grasping movements.

We investigated whether control of hand movements can be driven by visual information that is not consciously perceived. Subjects performed reach-to-grasp movements toward 2D virtual objects that were projected onto a rigid surface. On perturbed trials, the target object was briefly presented at a different orientation (±20° rotation) or different size (±20 % scaling) during movement.

Online processing of shape information for control of grasping.

When picking up objects, we tend to grasp at contact points that minimize slippage and torsion, which depend on the particular shape. Normally, grasp points could be planned before initiating movement. We tested whether grasp points can be determined during online control.

A 12-MONTH, SINGLE-MASKED, RANDOMIZED CONTROLLED STUDY OF EYES WITH PERSISTENT DIABETIC MACULAR EDEMA AFTER MULTIPLE ANTI-VEGF INJECTIONS TO ASSESS THE EFFICACY OF THE DEXAMETHASONE-DELAYED DELIVERY SYSTEM AS AN ADJUNCT TO BEVACIZUMAB COMPARED WITH CONTINUED BEVACIZUMAB MONOTHERAPY.

Purpose: To determine whether a dexamethasone intravitreal implant 0.7 mg (dexamethasone delivery system [DDS], Ozurdex) combined with bevacizumab 1.25 mg (Avastin) provides greater benefit than bevacizumab monotherapy in eyes with diabetic macular edema with incomplete response to multiple antivascular endothelial growth factor injections.

Perceptual biases and cue weighting in perception of 3D slant from texture and stereo information.

Multiple cues are typically available for perceiving the 3D slant of surfaces, and slant perception has been used as a test case for investigating cue integration. Previous evidence suggests that texture and stereo slant cues contribute in an optimal Bayesian manner. We tested whether a Bayesian model could also account for perceptual underestimation of slant from texture.

Reliability and relative weighting of visual and nonvisual information for perceiving direction of self-motion during walking.

Direction of self-motion during walking is indicated by multiple cues, including optic flow, nonvisual sensory cues, and motor prediction. I measured the reliability of perceived heading from visual and nonvisual cues during walking, and whether cues are weighted in an optimal manner. I used a heading alignment task to measure perceived heading during walking.

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation.

A number of human cancers harbor somatic point mutations in the genes encoding isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2). These mutations alter residues in the enzyme active sites and confer a gain-of-function in cancer cells, resulting in the accumulation and secretion of the oncometabolite (R)-2-hydroxyglutarate (2HG). We developed a small molecule, AGI-6780, that potently and selectively inhibits the tumor-associated mutant IDH2/R140Q.

Symmetry facilitates shape constancy for smoothly curved 3D objects.

We tested whether the presence of symmetry improves shape discrimination across changes in viewpoint and lighting for smoothly curved 3D objects. We constructed symmetric and asymmetric versions of random 3D shapes by manipulating their spherical harmonic representations. Matched objects had the same power spectra and appear highly similar except for the presence of symmetry.

Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo.

Optimization of a series of R132H IDH1 inhibitors from a high throughput screen led to the first potent molecules that show robust tumor 2-HG inhibition in a xenograft model. Compound 35 shows good potency in the U87 R132H cell based assay and ∼90% tumor 2-HG inhibition in the corresponding mouse xenograft model following BID dosing. The magnitude and duration of tumor 2-HG inhibition correlates with free plasma concentration.

Stereo improves 3D shape discrimination even when rich monocular shape cues are available.

We measured the ability to discriminate 3D shapes across changes in viewpoint and illumination based on rich monocular 3D information and tested whether the addition of stereo information improves shape constancy. Stimuli were images of smoothly curved, random 3D objects. Objects were presented in three viewing conditions that provided different 3D information: shading-only, stereo-only, and combined shading and stereo.