Publications by authors named "Jeffrey S Hatfield"
Cocaine use presents a worldwide public health problem with high socioeconomic cost. No current pharmacologic treatments are available for cocaine use disorder (CUD) or cocaine toxicity. To explore pharmaceutical treatments for tthis disorder and its sequelae we analyzed gene expression data from post-mortem brain tissue of individuals with CUD who died from cocaine-related causes with matched cocaine-free controls (n = 71, M = 39.
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- The study focuses on a new method, the Microplate Feeder Assay (MFA), for measuring food intake in Drosophila flies to understand various traits related to consumption.
- The MFA uses absorbance to quantify liquid food consumption and includes a tracer dye to track volume changes in a microplate setup.
- A specially designed 3D-printed device increases the efficiency of testing by allowing individual flies to access multiple wells, facilitating high throughput analysis of food preferences and consumption patterns.
Whereas the neurological effects of cocaine have been well documented, effects of acute cocaine consumption on genome-wide gene expression across the brain remain largely unexplored. This question cannot be readily addressed in humans but can be approached using the model, where gene expression in the entire brain can be surveyed at once. Flies exposed to cocaine show impaired locomotor activity, including climbing behavior and startle response (a measure of sensorimotor integration), and increased incidence of seizures and compulsive grooming.
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