Publications by authors named "Jeffrey Q Nguyen"
TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells.
Cancer Biol Ther
January 2017
Article Synopsis
- Par-4 is a tumor-suppressor protein that selectively induces apoptosis in cancer cells, and understanding its regulation is crucial for developing new cancer treatments.
- Research identified TRIM21 as a novel interacting partner of Par-4, which downregulates Par-4 levels in response to the chemotherapy drug cisplatin.
- High TRIM21 levels correlate with increased resistance to cisplatin in colon cancer cells and predict poorer survival outcomes in pancreatic cancer patients, suggesting it as a potential therapeutic target and prognostic marker.