Publications by authors named "Jeffrey Netto"
Light transmission aggregometry (LTA) is regarded as the gold standard in platelet function diagnostics. However, there is a relevant degree of interlaboratory variability in practical applications. The aim of the present study was to develop a practicable laboratory comparison on LTA and to analyze differences and influencing factors in regard to standardization in five specialized hemostaseological centers.
View Article and Find Full Text PDFKnowledge about cardiac and inflammatory biomarkers in patients with stable coronary artery disease (CAD) is limited. To address this, we analyzed 3072 patients (36% female) with a median follow-up of 10 years in the Leipzig LIFE Heart Study with suspected CAD with coronary angiography. Selected biomarkers included troponin T (hsTNT), N-terminal pro B-type natriuretic peptide (NT-proBNP), copeptin, C-reactive protein (hsCRP), and interleukin-6 (IL-6).
View Article and Find Full Text PDFBackground For many patients with end-stage liver disease, liver transplantation represents the only curative therapy. Transplant recipients are scored and ranked using the model for end-stage liver disease (MELD/MELD-Na). Circulatory impairment is known to deteriorate outcomes; however, it is not incorporated into the current allocation system's score.
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- The study investigated how stress affects hormone levels, specifically looking at salivary cortisone's effectiveness as a stress biomarker during a standardized stress test.
- Healthy young men participated in tests where their hormonal responses and psychological states were measured through various methods including blood and saliva samples.
- Results showed that salivary cortisone had a strong correlation with self-reported anxiety and heart rate increases, suggesting it could be a reliable indicator of stress with potential implications for future research.
Article Synopsis
- Surgical procedures, both laparoscopic and conventional, induce stress responses in patients that can influence recovery outcomes, with this study focusing on stress biomarkers like copeptin and steroid hormones during colorectal surgery.* -
- Eleven patients experienced minimally invasive surgery while ten underwent conventional open surgery, and blood samples were analyzed at different surgery stages to measure stress-related biomarker responses.* -
- Results indicated that stress biomarkers, particularly cortisol and glucose, decreased more quickly to baseline levels after minimally invasive surgery compared to open surgery, suggesting a different stress response that may affect long-term recovery.*
Background: The LIFE-Adult-Study is a population-based cohort study, which has recently completed the baseline examination of 10,000 randomly selected participants from Leipzig, a major city with 550,000 inhabitants in the east of Germany. It is the first study of this kind and size in an urban population in the eastern part of Germany. The study is conducted by the Leipzig Research Centre for Civilization Diseases (LIFE).
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