Two distinct oral routes of misoprostol in mifepristone medical abortion: a randomized controlled trial.

Objective: To study the efficacy, safety, and acceptability of oral immediately swallowed and buccal misoprostol 800 mcg after mifepristone 200 mg for terminating pregnancy through 63 days since the last menstrual period (LMP).

Methods: This seven-site study randomly assigned 966 women seeking abortions to oral or buccal misoprostol 800 mcg 24-36 hours after mifepristone 200 mg with 7-14-day follow-up.

Results: Success rates in the oral and buccal groups were 91.