Publications by authors named "Jeffrey Merlin"
Article Synopsis
- Antibody-drug conjugates are a new class of cancer treatments that are becoming more widely used, but they come with various toxicities and complications that need to be managed, especially in emergencies.
- Common side effects include diarrhea, nausea, rash, and peripheral neuropathy, while severe conditions like interstitial lung disease and sinusoidal obstruction syndrome can pose serious health risks.
- Rare but critical issues include cardiac effects, ocular problems, and tumor lysis syndrome, which require careful monitoring and prompt medical intervention.
Diagnosis and management of immune-related adverse effects of immune checkpoint therapy in the emergency department.
J Am Coll Emerg Physicians Open
December 2020
Rapid advances in cancer immunotherapy using immune checkpoint inhibitors have led to significantly improved survival. Rapid identification of the toxicity syndromes associated with these therapeutic agents is very important for emergency physicians because the population of patients diagnosed with cancer is increasing and cancer therapies including immune checkpoint inhibitors have become the first-line treatment for more and more types of cancer. The emergency medicine literature lags behind rapid advances in oncology, and oncology guidelines for rapid recognition and management of these emerging toxicity syndromes are not familiar to emergency physicians.
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