The Prevalence of Latent Tuberculosis Infection in the United States.

Rationale: Individuals with latent tuberculosis infection (LTBI) represent a reservoir of infection, many of whom will progress to tuberculosis (TB) disease. A central pillar of TB control in the United States is reducing this reservoir through targeted testing and treatment.

Objectives: To estimate the prevalence of LTBI in the United States using the tuberculin skin test (TST) and an IFN-γ release assay.