Publications by authors named "Jeffrey M Chalfant"
Shift work chronically disrupts circadian rhythms and increases the risk of developing cardiovascular disease. However, the mechanisms linking shift work and cardiovascular disease are largely unknown. The goal of this study was to investigate the effects of chronically shifting the light-dark (LD) cycle, which models the disordered exposure to light that may occur during shift work, on atherosclerosis.
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- Abnormal meal timing, like skipping breakfast and snacking late at night, is linked to obesity in humans and mice due to disrupted eating habits.
- A study compared the effects of high-fat diets on obesity-prone (C57BL/6J and 129X1/SvJ) versus obesity-resistant (SWR/J and BALB/cJ) male mice over six weeks.
- Results showed that obesity-prone mice not only gained more weight but also experienced a significant reduction in their daily eating rhythm amplitude on a high-fat diet, while their locomotive activity remained unchanged.
Disruption of the circadian system caused by disordered exposure to light is pervasive in modern society and increases the risk of cardiovascular disease. The mechanisms by which this happens are largely unknown. ApolipoproteinE-deficient (ApoE) mice are studied commonly to elucidate mechanisms of atherosclerosis.
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