Publications by authors named "Jeffrey Lightfoot"
Comprehensive management of panic disorder involves a wide array treatments and interventions to reduce symptoms and increase functionality. This chapter provides an overview of the pharmacologic treatment of panic disorder including aspects of assessment, treatment selection and the biologic mechanisms of the illness.
View Article and Find Full Text PDFStudy Objective: Community-associated methicillin-resistant Staphylococcus aureus is now the leading cause of uncomplicated skin abscesses in the United States, and the role of antibiotics is controversial. We evaluate whether trimethoprim-sulfamethoxazole reduces the rate of treatment failures during the 7 days after incision and drainage and whether it reduces new lesion formation within 30 days.
Methods: In this multicenter, double-blind, randomized, placebo-controlled trial, we randomized adults to oral trimethoprim-sulfamethoxazole or placebo after uncomplicated abscess incision and drainage.
Article Synopsis
- The study explores xanomeline, a muscarinic receptor agonist, as a potential treatment for schizophrenia, particularly for cognitive impairment and negative symptoms.
- In a pilot study with 20 subjects, xanomeline was found to be significantly more effective than a placebo on key clinical outcome measures like BPRS and PANSS scores.
- The findings suggest that xanomeline improved cognitive functions, especially in verbal learning and short-term memory, warranting further research into its therapeutic use for schizophrenia.
It is recognized that persons with schizophrenia tend to cope with stress in a relatively avoidant and ineffectual manner and that this coping style is linked to poorer outcome. Less is understood, however, about the interrelationship between symptoms, deficits in neurocognition and coping style in schizophrenia. To determine the extent to which various neurocognitive deficits and symptoms are related to coping style in schizophrenia, measures of positive symptoms, negative symptoms, state and trait anxiety levels, verbal memory and executive function were correlated with self-report of preference for a range of active and avoidant coping strategies.
View Article and Find Full Text PDFObjective: The purpose of this study was to investigate the effectiveness of zonisamide in the treatment of bipolar depression.
Method: Ten patients with DSM-IV bipolar disorder, depressed phase, who had either not tolerated or not responded to previous treatments were given zonisamide in this add-on open-label study. Zonisamide treatment was started at 100 mg/day and increased by 100 mg every 2 weeks to a maximum of 300 mg/day in divided doses (b.