The Prevalence of Persistent Toe Walking in Children With and Without Autism Spectrum Disorder and the Odds of Subsequent Surgery.

Persistent toe walking is associated with autism spectrum disorder. The true prevalence of persistent toe walking and odds of progression to surgery in children with and without autism remains unclear. This retrospective descriptive study identified patients ages 3 to 17 years who were enrolled in our healthcare system over a 2-year period.

The Effect of Adolescent Idiopathic Scoliosis on Natural Delivery and Epidural Use in Pregnant Females: A Matched Cohort Study.

Study Design: Retrospective matched cohort study.

Objective: The aim of this study was to determine whether females with idiopathic scoliosis (IS), both with and without spine fusion, experience different rates of cesarean section (CS) and epidural anesthesia (EA) than females without scoliosis.

Summary Of Background Data: IS is a common spine condition with a higher prevalence in females.

The Demographics and Epidemiology of Infantile, Juvenile, and Adolescent Idiopathic Scoliosis in a Southern California Integrated Health Care System.

Study Design: Prognostic study, Level III.

Objectives: The aim of this study was to determine the incidence and demographics of idiopathic scoliosis (IS) in a large cohort of children in a Southern California integrated healthcare system, and to identify the demographic or clinical factors associated with the greatest risk of IS.

Summary Of Background Data: Although many authors have reported on the incidence and prevalence of IS in children, there have been few incidence studies in the United States on large, self-contained populations.

Effect of an RN-Led Medication Teaching Initiative on Psychiatric Recidivism.

This quality improvement (QI) project analyzed the impact of RN-led medication teaching on readmissions of adult patients discharged from a Midwest psychiatric veterans' hospital. Data on patient participation in the initiative, outpatient medication adherence, and annual 30-day readmission rates were gathered from electronic medical records (EMR) and patient discharge logs from years 2017 and 2018. Forty-three percent of RNs engaged in the initiative.

Demographics and Epidemiology of Osteochondritis Dissecans of the Elbow Among Children and Adolescents.

Background: Osteochondritis dissecans (OCD) of the elbow is a disorder of subchondral bone and articular cartilage, of which the incidence among children is not clearly known.

Purpose: To assess the demographics and epidemiology of OCD of the elbow among children.

Study Design: Cross-sectional study; Level of evidence, 3.

What are the Demographics and Epidemiology of Legg-Calvé-Perthes Disease in a Large Southern California Integrated Health System?

Background: Although many authors have reported the incidence of Legg-Calvé-Perthes disease (LCPD), there have been few incidence studies in the United States on large, self-contained populations such as those within an integrated health system. Understanding the epidemiology and demographics of LCPD in this setting may help clinicians identify patients at the greatest risk and aid in diagnosis and subsequent treatment.

Questions/purposes: In this study we sought (1) to determine the incidence and demographics of LCPD in a large cohort of children and adolescents in a Southern California integrated healthcare system, and (2) to identify any demographic or clinical factors (such as age, sex, race/ethnicity, or BMI) that are independently associated with LCPD.

Childhood Obesity is Associated With Osteochondritis Dissecans of the Knee, Ankle, and Elbow in Children and Adolescents.

Background: Osteochondritis dissecans (OCD) is a joint disorder of the subchondral bone and articular cartilage whose association with obesity in children is not clearly known. The purpose of this study was to assess the magnitude of the association between childhood obesity and the occurrence of OCD of the knee, ankle, and elbow in children.

Methods: A retrospective chart review of an integrated health system was performed on OCD patients aged 2 to 19 from 2007 to 2011, with over 1 million patients in this cohort.

Incidence of Osteochondritis Dissecans in Adults.

Background: Osteochondritis dissecans (OCD) has frequently been described in children and adolescents, but cases of OCD in adults are certainly encountered. Little has been published on the epidemiology of OCD in adult patients.

Purpose: To assess the frequency of OCD lesions in adults and assess the risk by age, sex, and ethnicity.

The Incidence of Surgery in Osteochondritis Dissecans in Children and Adolescents.

Background: The frequency of osteochondritis dissecans (OCD), a disorder of the subchondral bone and articular cartilage, is not well described.

Purpose: To assess the frequency of pediatric OCD lesions that progress to surgery based on sex, joint involvement, and age.

Study Design: Descriptive epidemiology study.

Osteochondritis dissecans of the ankle in children and adolescents: demographics and epidemiology.

Background: Osteochondritis dissecans (OCD) of the ankle is a disorder of the talar or distal tibial subchondral bone and articular cartilage whose incidence in children is not clearly known.

Purpose: To assess the demographics and epidemiology of OCD of the ankle in children.

Study Design: Descriptive epidemiologic study.

Osteochondritis dissecans of the knee: pathoanatomy, epidemiology, and diagnosis.

Although several hypotheses have been described to explain the cause of osteochondritis dissecans, no single hypothesis has been accepted in the orthopedic community. Given its increased incidence among athletes, most in the sports medicine community agree that repetitive microtrauma plays at least some role in its development. Knowledge regarding the epidemiology and pathoanatomy of osteochondritis dissecans has helped the understanding of osteochondritis dissecans; however, much is still to be learned about this condition and its cause.

The demographics and epidemiology of osteochondritis dissecans of the knee in children and adolescents.

Background: Osteochondritis dissecans (OCD) is a disorder of subchondral bone and articular cartilage whose incidence in children is not clearly known.

Purpose: The purpose of this study was to assess the demographics and epidemiology of OCD of the knee in children.

Study Design: Descriptive epidemiology study.

Associations between childhood obesity and upper and lower extremity injuries.

Objectives: To estimate the overall and age-specific associations between obesity and extremity musculoskeletal injuries and pain in children.

Methods: This cross-sectional study used information from electronic medical records of 913178 patients aged 2-19 years enrolled in an integrated health plan in the period 2007-2009. Children were classified as underweight, normal weight, overweight, or moderately/extremely obese and, using multivariable logistic regression methods, the associations between weight class and diagnosis of upper or lower extremity fractures, sprains, dislocations and pain were calculated.

A new flexible brace used in the Ponseti treatment of talipes equinovarus.

The objective was to introduce a flexible brace abduction brace in the Ponseti treatment of clubfeet. Eight patients undergoing Ponseti treatment for talipes equinovarus were assessed. Brace compliance and incidence of relapses were assessed.

Efficacy of a new computer-aided design/computer-aided manufacture orthosis in the treatment of adolescent idiopathic scoliosis.

To report on the initial experience with the Los Angeles brace, a new computer-aided design/computer-aided manufacture brace used in the treatment of idiopathic scoliosis. This was a retrospective review of 40 idiopathic scoliosis patients who completed treatment with this new computer-aided design/computer-aided manufacture brace. In-brace correction averaged 51% for the primary curves, with corrections of 53 and 22% for girls and boys, respectively.

The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states.

The third and most recently identified Parkinson's disease-linked variant of the neuronal protein alpha-synuclein to be identified (E46K) results in widespread brain pathology and early onset Parkinson symptoms (Zarranz et al. (2004) Ann. Neurol.

Impact of an Electronic Health Record on oncologists' clinic time.

The use of Electronic Health Records (EHRs) has been widely advocated to transform health-care delivery by improving quality, safety, and efficiency. Compared to a paper-based system, EHRs offer better access to clinical data and facilitate order entry and decision support. However, the benefits provided by EHRs do not eliminate the need to assess how such systems alter clinician time utilization.

The N-terminal repeat domain of alpha-synuclein inhibits beta-sheet and amyloid fibril formation.

The conversion of alpha-synuclein into amyloid fibrils in the substantia nigra is linked to Parkinson's disease. Alpha-synuclein is natively unfolded in solution, but can be induced to form either alpha-helical or beta-sheet structure depending on its concentration and the solution conditions. The N-terminus of alpha-synuclein comprises seven 11-amino acid repeats (XKTKEGVXXXX) which can form an amphipathic alpha-helix.