Publications by authors named "Jeffrey Kaesberg"
Article Synopsis
- The Sendai virus P-L RNA polymerase complex initiates RNA synthesis by binding to the viral nucleocapsid template through interactions between its P subunit and NP protein.
- Truncations and mutations in the C-terminal region of NP revealed that while specific amino acids are critical for the NP(0)-P complex formation, certain residues (aa 492-524) are nonessential for overall protein activity.
- Key regions within NP (aa 462-471 and 440-461) are crucial for polymerase binding and NP self-assembly, but mutations in aa 435-491 indicated that charged amino acids in this area were not critical for these processes.
