Publications by authors named "Jeffrey J Taulbee"
Taq DNA polymerase functions at elevated temperatures with fast conformational dynamics-regimes previously inaccessible to mechanistic, single-molecule studies. Here, single-walled carbon nanotube transistors recorded the motions of Taq molecules processing matched or mismatched template-deoxynucleotide triphosphate pairs from 22° to 85°C. By using four enzyme orientations, the whole-enzyme closures of nucleotide incorporations were distinguished from more rapid, 20-μs closures of Taq's fingers domain testing complementarity and orientation.
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- Scientists created a new tool that can quickly find tiny differences in genes that might help with medical research and testing.
- The tool uses special technology to detect genes without having to make more copies of them, making it faster.
- It can tell the difference between normal genes and versions with a small change in just one hour, which is super useful for diseases like sickle cell disease.