Publications by authors named "Jeffrey J Burkhardt"
Drug Metab Dispos
December 2007
Article Synopsis
- The study investigated how the drug bicifadine is metabolized in the liver cells of mice, rats, monkeys, and humans using advanced chromatography techniques.
- Two main metabolic pathways were identified: one dependent on NADPH that converts bicifadine into a hydroxymethyl metabolite (M2), primarily involving the enzyme CYP2D6, and another independent pathway that produces a lactam metabolite (M12) through monoamine oxidase (MAO)-B.
- The research highlights that in humans, the key enzymes for bicifadine metabolism are CYP2D6 and MAO-B, with notable differences in metabolic activity across the different species.
