Selective Depletion of Staphylococcus aureus Restores the Skin Microbiome and Accelerates Tissue Repair after Injury.

Our skin is home to a diverse community of commensal microorganisms integral to cutaneous function. However, microbial dysbiosis and barrier perturbation increase the risk of local and systemic infection. Staphylococcus aureus is a particularly problematic bacterial pathogen, with high levels of antimicrobial resistance and direct association with poor healing outcome.

A Bayesian Motivated Two-Sample Test Based on Kernel Density Estimates.

A new nonparametric test of equality of two densities is investigated. The test statistic is an average of log-Bayes factors, each of which is constructed from a kernel density estimate. Prior densities for the bandwidths of the kernel estimates are required, and it is shown how to choose priors so that the log-Bayes factors can be calculated exactly.

Pre-Clinical Assessment of Single-Use Negative Pressure Wound Therapy During Porcine Wound Healing.

Traditional negative pressure wound therapy (tNPWT) systems can be large and cumbersome, limiting patient mobility and adversely affecting quality of life. PICO™, a no canister single-use system, offers a lightweight, portable alternative to tNPWT, with improved clinical performance. The aim of this study was to determine the potential mechanism(s) of action of single-use NPWT (sNPWT) versus tNPWT.

Effects of the no interruption zone on distraction levels, withdrawal times, and adenoma detection rates of colonoscopy.

Background: The creation of no interruption zones (NIZs) reduces medical errors by reducing distraction levels on hospital wards. To date, the effect of a NIZ during colonoscopy has not been evaluated.

Aims: Assess the effects of a NIZ during colonoscopy, on distraction levels, withdrawal times, and adenoma detection rates (ADRs).

BK virus as a potential co-factor for HPV in the development of cervical neoplasia.

Cervical cancer is the third most common type of cancer in women worldwide. A persistent infection with high risk (HR) human papillomavirus (HPV) is necessary for cervical cancer to occur. However, the great majority of women that are infected with HR-HPV will not develop cervical cancer, indicating that HR-HPV alone is not adequate to drive the development of cervical cancer, suggesting the involvement of cofactors.

Density Estimation in Several Populations With Uncertain Population Membership.

We devise methods to estimate probability density functions of several populations using observations with uncertain population membership, meaning from which population an observation comes is unknown. The probability of an observation being sampled from any given population can be calculated. We develop general estimation procedures and bandwidth selection methods for our setting.

Local and omnibus goodness-of-fit tests in classical measurement error models.

We consider functional measurement error models, i.e. models where covariates are measured with error and yet no distributional assumptions are made about the mismeasured variable.

Bias properties of Bayesian statistics in finite mixture of negative binomial regression models in crash data analysis.

Factors that cause heterogeneity in crash data are often unknown to researchers and failure to accommodate such heterogeneity in statistical models can undermine the validity of empirical results. A recently proposed finite mixture for the negative binomial regression model has shown a potential advantage in addressing the unobserved heterogeneity as well as providing useful information about features of the population under study. Despite its usefulness, however, no study has been found to examine the performance of this finite mixture under various conditions of sample sizes and sample-mean values that are common in crash data analysis.

Hypertrichosis of vellus hairs of the malar region after unilateral treatment with bimatoprost.

Purpose: To report hypertrichosis and increased pigmentation of vellus hairs of the malar region associated with topical bimatoprost usage.

Design: Interventional case report

Methods: In a female Hispanic patient with open-angle glaucoma, hypertrichosis, and increased pigmentation of the vellus hairs of the malar region developed after 8 weeks of unilateral treatment with bimatoprost. Increased growth of eyelashes was also noted.

The role of oxidised regenerated cellulose/collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing.

Irrespective of underlying chronic wound pathology, delayed wound healing is normally characterised by impaired new tissue formation at the site of injury. It is thought that this impairment reflects both a reduced capacity to synthesize new tissue and the antagonistic activities of high levels of proteinases within the chronic wound environment. Historically, wound dressings have largely been passive devices that offer the wound interim barrier function and establish a moist healing environment.

RUST FUNGI AND HOST PLANT COEVOLUTION: DO PRIMITIVE HOSTS HARBOR PRIMITIVE PARASITES?

Abstract- The classical view of rust phylogeny is that rusts found on ferns and conifers are primitive, while rusts that parasitize angiosperms are advanced. This belief was based on the theory that primitive hosts harbor primitive parasites; that is, it assumed coevolution (co-speciation) of hosts and parasites. A cladistic analysis of 30 genera and 28 characters representative of the major patterns of rust fungi diversity is presented.