Safety climate, hearing climate and hearing protection device use among transportation road maintainers.

Background: It is important to understand workplace factors including safety climate that influence hearing protection device (HPD) use. We sought to investigate the association between HPD use, safety climate, and hearing climate, a new measure specific to hearing.

Methods: A survey was developed and distributed among transportation "maintainers" who perform road maintenance and repair.

Novel applications of recombinant factor VIIa for the management of pediatric coagulopathic diseases.

Recombinant factor VIIa (rFVIIa) was envisioned for the treatment of bleeding in hemophilia patients with inhibitors. In response to tissue factor expressed upon vessel wall injury, rFVIIa amplifies the thrombin burst primarily on membrane surfaces, including activated platelets. Because it is functional at a key point in the clotting cascade, rFVIIa shows promise as a therapeutic option for various bleeding situations.