Feed rations fed by US dairy producers.

Feed rations used by US dairy producers are estimated using data from the USDA Agricultural Resource Management Survey. The 2016 dairy version of the survey was used, in which 955 respondents fully responded on feed usage. Surveyed farms milked ≥10 cows and were located in dairy states that together produced 96.

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo.

Nonselective inhibitors of human histone deacetylases (HDAC) are known to have antitumor activity in mice in vivo, and several of them are under clinical investigation. The first of these, Vorinostat (SAHA), has been approved for treatment of cutaneous T-cell lymphoma. Questions remain concerning which HDAC isotype(s) are the best to target for anticancer activity and whether increased efficacy and safety will result with an isotype-selective HDAC inhibitor.