Mechanical failure of the Mobi-C implant for artificial cervical disc replacement: report of 4 cases.

Cervical spondylosis is one of the most commonly treated conditions in neurosurgery. Increasingly, cervical disc replacement (CDR) has become an alternative to traditional arthrodesis, particularly when treating younger patients. Thus, surgeons continue to gain a greater understanding of short- and long-term complications of arthroplasty.

Blood serum antibody analysis and long-term follow-up of patients treated with recombinant human bone morphogenetic protein-2 in the lumbar spine.

Study Design: Prospective, longitudinal cohort study.

Objective: To examine the incidence of bone morphogenetic protein (BMP)-2 antibody formation in lumbar spine applications and to determine the clinical significance of an antibody response.

Summary Of Background Data: Immune responses can affect the safety and efficacy profile of recombinant proteins.