Publications by authors named "Jeffrey D Benner"
The aim of this study is to determine if extended-release, bioabsorbable, subcutaneous naltrexone (NTX) implants can mitigate respiratory depression after an intravenous injection (IV) of fentanyl. Six different BIOabsorbable Polymeric Implant Naltrexone (BIOPIN) formulations, comprising combinations of Poly-d,l-Lactic Acid (PDLLA) and/or Polycaprolactone (PCL-1 or PCL-2), were used to create subcutaneous implants. Both placebo and naltrexone implants were implanted subcutaneously in male dogs.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates whether naltrexone (NTX) implants can prevent respiratory depression caused by fentanyl in rats.
- Researchers used bioabsorbable implants made from two polymers, administered either as a placebo or containing NTX, and measured the effects after 3.5 months.
- Results showed that while placebo rats experienced significant respiratory depression when given fentanyl, those with NTX implants maintained normal respiratory rates, indicating NTX effectively blocked the drug’s respiratory effects.
Low-Dose Intravitreal Methotrexate for Proliferative Vitreoretinopathy.
Ophthalmic Surg Lasers Imaging Retina
March 2023
Background And Objective: Proliferative vitreoretinopathy (PVR) has been mitigated by intravitreal methotrexate (MTX) 400 μg/0.1 mL in several studies. Here, we evaluate the results from a lower dose of MTX, 200 μg/0.
View Article and Find Full Text PDFIntravitreal methotrexate for the treatment of proliferative vitreoretinopathy.
BMJ Open Ophthalmol
April 2019
Background/aims: Preventing and treating proliferative vitreoretinopathy (PVR) remain a serious challenge for vitreoretinal surgeons. PVR is a devastating complication of retinal detachment that results in recurrent detachment and limits visual recovery. At present, there is no effective treatment for PVR.
View Article and Find Full Text PDFPurpose: The most difficult and unpredictable step of macular translocation surgery is creating the retinal detachment. The authors evaluated the efficacy of 2,4-dinitrophenol (2,4-DNP) to promote retinal detachment in the rabbit.
Methods: A vitrectomy was performed in each eye of a Dutch-belted rabbit.
Purpose: To report the complication of macular infarction after transpupillary thermotherapy (TTT) for the treatment of subfoveal choroidal neovascularization (CNV) due to age-related macular degeneration (AMD).
Design: Interventional case reports.
Methods: Among 107 consecutive patients with subfoveal CNV due to AMD, a 73-year-old woman with recurrent subfoveal classic choroidal neovascularization and a 76-year-old man with subfoveal occult choroidal neovascularization with adjacent areas of geographic retinal pigment epithelium atrophy noted a severe decrease in visual acuity and photopsias within hours of undergoing TTT.
Objectives: To report visual improvement following bilateral limited macular translocation for a patient with atrophic macular disease, and to discuss issues related to the selection of potential candidates for this technique.
Design: Case report.
Results: A 78-year-old woman with bilateral atrophic maculopathy and no choroidal neovascularization had slowly progressive loss of visual acuity for at least 17 months in the right eye and 25 months in the left eye.