Detection of singlet oxygen luminescence for experimental corneal rose bengal photodynamic antimicrobial therapy.

Rose bengal photodynamic antimicrobial therapy (RB-PDAT) treats corneal infection by activating rose bengal (RB) with green light to produce singlet oxygen (O). Singlet oxygen dosimetry can help optimize treatment parameters. We present a O dosimeter for detection of O generated during experimental RB-PDAT.

Molecular epidemiology and resistance profiles among healthcare- and community-associated keratitis isolates.

Purpose: To characterize the molecular, epidemiological, and resistance profiles of methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) keratitis isolates.

Patients And Methods: We used a combination of standard microbiological techniques and DNA microarray analysis to characterize the molecular and antibiotic resistance profiles of 75 keratitis isolates collected over an 11-year period (2006-2016).

Results: Two major USA clonal complexes (CC), CC5 (n=30, 40%) and CC8 (n=28, 37.