A second opinion: response to 100 professors.

Induced abortion is a controversial topic among obstetricians. "100 Professors" extolled the benefits of elective abortion in a Clinical Opinion published in AJOG. However, scientific balance requires the consideration of a second opinion from practitioners who care for both patients, and who recognize the humanity of both.

Assisted reproduction using donated embryos: outcomes from surveillance systems in six countries.

Background: Embryo donation, though less often performed than other assisted reproductive technology (ART), can represent an attractive option for couples who do not wish to discard their embryos remaining after IVF, and for those who cannot or should not conceive naturally. Clinicians and potential participants could benefit from information comparing outcomes of embryo donation with those of other ARTs, in various countries.

Methods: We analyzed outcome information from ART treatment cycles using 2001-2008 data from national surveillance systems in the USA, Canada, the UK, Australia, New Zealand and Finland.

Ulipristal acetate: contraceptive or contragestive?

Ulipristal acetate is the first selective progesterone receptor modulator approved for postcoital contraception in the US. It appears to be significantly more effective in inhibition of ovulation than other forms of emergency contraception. However, ulipristal acetate is structurally similar to mifepristone, and several lines of evidence suggest that a postfertilization mechanism of action is also operative.

Birth of twins unrelated to each other or to their gestational mother.

This report records the first documented instance of a birth in which twins, genetically unrelated to each other, were born to a mother genetically unrelated to either of them. After an extensive history of infertility with multiple unsuccessful treatments, a 42-year-old woman gave birth to healthy twins following transfer of three embryos from two different donor sources. DNA testing confirmed that the twins represented both sources.

Consecutive cervical pregnancies.

Objective: Report of a rare case of consecutive spontaneous cervical pregnancies.

Design: Case study.

Setting: Teaching hospital.

Variability of placental expression of cyclin E low molecular weight variants.

Cyclin E, a G(1) cyclin serving to activate cyclin-dependent kinase 2, is the only cyclin gene for which alternative splicing leading to structurally different proteins has been described. Different cyclin E proteins are present in tumor tissues but absent from normal (steady) tissues. Cyclin E contributes to the regulation of cell proliferation and ongoing differentiation and aging.

Changes of ovarian interstitial cell hormone receptors and behavior of resident mesenchymal cells in developing and adult rats with steroid-induced sterility.

In the present paper, we report that injection of testosterone propionate (500 microg) during the critical window of rat development (postnatal day 5) induces temporary appearance of aged interstitial cells in developing ovaries (days 7 and 10). Aged interstitial cells showed large size (> or = 12 microm), enhanced androgen receptor (AR) and low estrogen (ER) and luteinizing hormone receptor (LHR) expression. Although normal mature interstitial cells (large size and strong ER and LHR expression) appeared later (day 14), and ovaries of androgenized rats were similar to normal ovaries between days 14 and 35, ovaries of adult androgenized females showed only aged and no mature interstitial cells.