Publications by authors named "Jeffrey A Carrell"
B lymphocyte stimulator (BLyS) is a member of the TNF superfamily of cytokines. The biological activity of BLyS is mediated by three cell surface receptors: BR3/BAFF-R, TACI and BCMA. The expression of these receptors is highly restricted to B cells, both normal and malignant.
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- Mapatumumab and lexatumumab are human monoclonal antibodies that trigger cell death in various tumors by activating specific receptors, but their effectiveness can vary among different tumor types.
- The combination of these antibodies with the chemotherapeutic drug bortezomib has shown to enhance sensitivity in lung cancer cells that are resistant to the antibodies alone, particularly at low concentrations of bortezomib.
- This combination treatment activates the caspase cascade and increases levels of apoptosis regulators, indicating a need for further studies on their use together in patients with non-small cell lung cancer.