Hyaluronic acid-doxorubicin nanoparticles for targeted treatment of colorectal cancer.

Colorectal cancer, common in both men and women, occurs when tumors form in the linings of the colon. Common treatments of colorectal cancer include surgery, chemotherapy, and radiation therapy; however, many colorectal cancer treatments often damage healthy tissues and cells, inducing severe side effects. Conventional chemotherapeutic agents such as doxorubicin (Dox) can be potentially used for the treatment of colorectal cancer; however, they suffer from limited targeting and lack of selectivity.

Intracellular Delivery Using Nanosecond-Laser Excitation of Large-Area Plasmonic Substrates.

Efficiently delivering functional cargo to millions of cells on the time scale of minutes will revolutionize gene therapy, drug discovery, and high-throughput screening. Recent studies of intracellular delivery with thermoplasmonic structured surfaces show promising results but in most cases require time- or cost-intensive fabrication or lead to unreproducible surfaces. We designed and fabricated large-area (14 × 14 mm), photolithography-based, template-stripped plasmonic substrates that are nanosecond laser-activated to form transient pores in cells for cargo entry.

Diversion remains the standard of care for modern management of war-related rectal injuries.

Introduction: Management of rectal injuries in war-injured patients has evolved over time.

Methods: Retrospective review of records of patients sustaining war-related rectal injuries admitted to Walter Reed Army Medical Center from Iraq and Afghanistan.

Results: From 2003 to 2011, 67 males ages 18 to 40 sustained rectal injuries after secondary blast (64%), gunshot (33%), motor vehicle crash (1%), or helicopter crash (1%).

Outcomes of primary repair and primary anastomosis in war-related colon injuries.

Background: The role of primary repair (PR) of modern day war-related colon injuries remains controversial.

Methods: Retrospective review of medical records of combat-wounded soldiers with colon injuries sustained during March 2003 to August 2006 was conducted. Injuries were analyzed according to location: right (n = 30), transverse (n = 13), and left (n = 24) sided colon injuries.

Modern management of complex open abdominal wounds of war: a 5-year experience.

Background: Optimal management of the open abdomen remains controversial.

Study Design: Retrospective review of patients injured during Operations Enduring Freedom and Iraqi Freedom returning to Walter Reed Army Medical Center (WRAMC) from January 2003 to October 2007 for treatment of open abdomen.

Results: Three hundred fifty-four patients were evacuated to WRAMC after laparotomy, including 86 patients (24%) with open abdomen.

Prospective randomized study comparing sentinel lymph node evaluation with standard pathologic evaluation for the staging of colon carcinoma: results from the United States Military Cancer Institute Clinical Trials Group Study GI-01.

Background: The principal role of sentinel lymph node (SLN) sampling and ultrastaging in colon cancer is enhanced staging accuracy. The utility of this technique for patients with colon cancer remains controversial.

Purpose: This multicenter randomized trial was conducted to determine if focused assessment of the SLN with step sectioning and immunohistochemistry (IHC) enhances the ability to stage the regional nodal basin over conventional histopathology in patients with resectable colon cancer.

Venlafaxine-associated interstitial pneumonitis.

A 55-year-old woman was hospitalized with a 7-month history of progressive dyspnea on exertion and hypoxia despite a normal echocardiogram. The onset of her symptoms correlated with a dosage increase of venlafaxine. A multichannel computed tomography scan showed ground-glass opacities, and an open lung biopsy revealed interstitial pneumonitis consistent with extrinsic allergic alveolitis.

Liver repopulation after cell transplantation in mice treated with retrorsine and carbon tetrachloride.

Background: Efficiency of engraftment after liver cell transplantation is less than 1% under conventional conditions. Our aim was to develop a high-efficiency, nonsurgical, no-genetic-advantage mouse model of liver repopulation with transplanted cells.

Methods: Mice were conditioned with nonlethal doses of a cell cycle inhibitor, retrorsine, 70 mg/kg, to irreversibly block proliferation of native hepatocytes.

Laparoscopic management of abdominopelvic abscesses in tropical pyomyositis.

Tropical pyomyositis is a suppurative infectious disease of skeletal muscles. The most common causative organism is Staphylococcus aureus. Penicillin-resistant strains are frequently encountered.